Current status of and perspectives regarding neoadjuvant chemoradiotherapy for locally advanced esophageal squamous cell carcinoma

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• 作者：Hiroshi Saeki ; Yuichiro Nakashima ; Yoko Zaitsu ; Yasuo Tsuda ; Yuta Kasagi…
• 关键词：Esophageal carcinoma ; Preoperative treatment ; Effectiveness ; Complication ; Survival benefit ; Biomarker
• 刊名：Surgery Today
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：46
• 期：3
• 页码：261-267
• 全文大小：426 KB
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• 作者单位：Hiroshi Saeki (1)
  Yuichiro Nakashima (1)
  Yoko Zaitsu (1)
  Yasuo Tsuda (1)
  Yuta Kasagi (1)
  Koji Ando (1)
  Yu Imamura (1)
  Kippei Ohgaki (1)
  Shuhei Ito (1)
  Yasue Kimura (1)
  Akinori Egashira (2)
  Eiji Oki (1)
  Masaru Morita (2)
  Yoshihiko Maehara (1)
  
  1. Deptartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan
  2. Department of Gastroenterological Surgery, National Kyushu Cancer Center, Fukuoka, Japan
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Surgery
  Abdominal Surgery
  Thoracic Surgery
  Vascular Surgery
  Cardiac Surgery
  Surgical Oncology
  
• 出版者：Springer Japan
• ISSN：1436-2813

文摘

The significance of neoadjuvant chemoradiotherapy (NACRT) for esophageal squamous cell carcinoma (ESCC) remains controversial with regard to the pathological response and long-term survival. We herein review the current status of and future perspectives regarding NACRT followed by esophagectomy for locally advanced ESCC. Some studies have suggested that a pathological complete response with NACRT is more common in patients with ESCC than in those with adenocarcinoma and that NACRT provided a survival benefit limited to patients with ESCC. However, NACRT may increase the risk of postoperative complications after esophagectomy. It is obvious that a favorable pathological response is the most important factor for obtaining a survival benefit, although no established parameters have been implemented clinically to predict the response to NACRT. Prospective clinical studies and basic research studies to identify predictive biomarkers for the response to NACRT are needed to aid in the development of NACRT treatment strategies for patients with ESCC. Keywords Esophageal carcinoma Preoperative treatment Effectiveness Complication Survival benefit Biomarker