Association of clinical features of bone and joint lesions between children and parents with Kashin–Beck disease in Northwest China

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• 作者：Chun-xia Cao (1)
  Yin-gang Zhang (2)
  Shi-xun Wu (2)
  Mohammad Imran Younas (1)
  Xiong Guo (1)
  
• 关键词：Children ; Clinical features ; Diagnosis ; Kashin–Beck disease ; Parents
• 刊名：Clinical Rheumatology
• 出版年：2013
• 出版时间：September 2013
• 年：2013
• 卷：32
• 期：9
• 页码：1309-1316
• 全文大小：194KB
• 参考文献：1. Sokoloff L (1989) The history of Kashin-Beck disease. N Y State J Med 89:343-51
  2. Mathieu F, Begaux F, Lan ZY, Sueteus C, Hinsenkamp M (1997) Clinical manifestations of Kashin-Beck disease in Nyemo Valley, Tibet. Int Orthop 21:151-56 CrossRef
  3. Guo X (2008) Progression and prospect of etiology and pathogenesis of Kashin-Beck disease. J Xi’an Jiaotong Univ Med Sci 29:481-88
  4. Schepman K, Engelbert RH, Visser MM, Yu C, de Vos R (2011) Kashin Beck disease: more than just osteoarthrosis: a cross-sectional study regarding the influence of body function-structures and activities on level of participation. Int Orthop 35:767-76 CrossRef
  5. Guo X (2001) Diagnostic, clinical and radiological characteristics of Kashin-Beck disease in Shaanxi Province, PR China. Int Orthop 25:147-50 CrossRef
  6. Mathieu F, Begaux F, Suetens C, De Maretelaer V, Hinsenkamp M (2001) Anthropometry and clinical features of Kashin-Beck disease in central Tibet. Int Orthop 25:138-41 CrossRef
  7. Farooq U, Guo X, Chuang LH, Fang H, Zhuang GH, Xia CT (2011) Measuring health-related quality of life in Kashin-Beck disease using EQ-5D. Qual Life Res 20:425-29 CrossRef
  8. Guo X, Zhang SHY, Mo DX (1993) The role of low selenium in occurrence of Kashin-Beck disease. Chin J Ctrl Endem Dis 8(2):82-4
  9. Voshchenko AV, Ivanov VN (1990) Kashin-Beck disease in the USSR: Proceedings of international workshop on Kashin-Beck disease and non-communicable diseases. World Health Organization 152-96
  10. Allander E (1994) Kashin-Beck disease. An analysis of research and public health activities based on a bibliography 1849-1992. Scand J Rheumatol Suppl 99:1-6 CrossRef
  11. Zhai Sh (1990) Investigation on the relationship between Kashin-Beck disease and drinking water. In: Proceedings of international workshop on Kashin-Beck disease and noncommunicable diseases. World Health Organization 96-101
  12. Yasuyuki E (1990) An outline of history of research on Kashin-Beck disease in Japan. In: Proceedings of international workshop on Kashin-Beck disease and non-communicable diseases. World Health Organization 149-151
  13. Zhang WH, Neve J, Xu JP, Vanderpas J, Wang ZL (2001) Selenium, iodine and fungal contamination in Yulin District (People’s Republic of China) endemic for Kashin-Beck disease. Int Orthop 25:188-90 CrossRef
  14. Yamamuro T (2001) Kashin-Beck disease: a historical overview. Int Orthop 25:134-37 CrossRef
  15. Suetens C, Moreno-Reyes R, Chasseur C, Mathieu F, Begaux F, Haubruge E, Durand MC, Neve J, Vanderpas J (2001) Epidemiological support for a multifactorial aetiology of Kashin-Beck disease in Tibet. Int Orthop 25:180-87 CrossRef
  16. Zhao QM, Guo X, Lai JH, Tan WH, Wang WZH, Dang XQ (2012) Association of TNF-α and Fas gene promoter polymorphism with the risk of Kashin-Beck disease in Northwest Chinese population. Clin Rheumatol 31:1051-057 CrossRef
  17. Zhou ZK, Shen B, Pei FX et al (2009) Relation between affected big joints and classification of Kashin-Beck disease in adults of Tibetan. Chin J Bone Jt Surg 2(5):352-56
  18. Malaisse F, Mathieu F (2008) Big bone disease: a multidisciplinary approach of KBD in Tibet Autonomous Region (P.R. China), vol 15. Les Presses Agronomiques de Gembloux, ASBL, Belgium, pp 70-8
  19. Chinese Ministry of Health (1994) Diagnosis criteria of Kashin-Beck disease. Chin J Endem 13:309
  20. Moreno-Reyes R, Suetens C, Mathieu F et al (1998) Kashin-Beck osteoarthropathy in rural Tibet in relation to selenium and iodine status. N Engl J Med 339:1112-120 CrossRef
  21. Lü AL, Guo X, Aisha MMT, Shi XW, Zhang YZH, Zhang YY (2011) Kashin-Beck disease and Sayiwak disease in China: prevalence and a comparison of the clinical manifestations, familial aggregation, and heritability. Bone 48:347-53 CrossRef
  22. Chinese Ministry of Health (2010) Diagnostic criteria of Kashin-Beck disease in China (WS/T207-2010). CMH publication no. 29062-2010
  23. Yang JB, Wang ZW, Liu J, He F (1994) Criteria of diagnosis for Kashin-Beck disease. Chin J Endemicol 13(5):309-17
  24. Yong L, Zhou ZK, Shen B, Yang J, Kang P et al (2012) Clinical features of Kashin-Beck Disease in adults younger than 50?years of age during a low incidence period: severe elbow and knee lesions. Clin Rheumatol. doi:10.1007/s10067-012-2115-0
  25. Shi XW, Guo X, Ren FL, Lu AL, Zhang YZ (2008) Familial aggregation and sibling heritability in Kashin-Beck disease. Nan Fang Yi Ke Da Xue Xue Bao 28(7):1187-189
  26. Zhang JG, Yang YSH (1991) Investigation of the familial aggregation of Kashin-Beck disease. Chin J Ctrl Endem Dis 3:76
  27. Shi XW, Guo X, Lv AL, Kang L, Zhou YL, Zhang YZ, Wu XM, Bai YD (2010) Heritability estimates and linkage analysis of 23 short tandem repeat loci on chromosomes 2, 11, and 12 in an endemic osteochondropathy in China. Scand J Rheumatol 39(3):259-65 CrossRef
  28. Khoury MJ, Beaty TH, Liang KY (1988) Can familial aggregation of disease be explained by familial aggregation of environmental risk factors? Am J Epidemiol 127:674-83
  29. Guo SW (2000) Familial aggregation of environmental risk factors and familial aggregation of disease. Am J Epidemiol 151:1121-131 CrossRef
  30. Zhu C (1987) Pathology of Kashin-Beck disease. In: Chen XC (ed) Advancement of pathology. People’s Health, Beijing, p 235
  31. Qian Z (1984) A study of radiographic findings in patients with Kashin-Beck disease. J Chin Radiol 18:274
  32. Wang YZ, Yang ZY, Louis AG, Zhu CR (1996) Kashin-Beck disease: radiographic appearance in the hand and wrist. Radiology 201:265-70
  33. Cao CX, Guo X, Zhang YZ (2011) Screening and model construction of the clinical diagnostic indictors for Kashin-Beck disease in adolescents. Chin J Endemiol 30(6):43-6
  34. Gao JQ, Qiu HL, Chen ZW (1994) Epidemiological investigation of Kashin-Beck disease in Qin Xian. ACAD J CZMC 8:309-11
  35. Ping ZG, Guo X, Wang FQ, Wang ZW (2004) Epidemiological characters of Kashin-Beck disease in nuclear families. Chin Epidemiol 25:848-51
  36. Wang ZW, Liu YQ, Song JC (1992) Familial aggregation of Kashin-Beck disease and epidemiological significance. Chin J Endem 11:295-96
  37. Zhang YZH, Guo X, Ping ZHG et al (2009) Main source of drinking water and familial aggregation of Kashin-Beck disease: a population based on case-control family study. AEP 19(8):560-66
  38. Guo X, Yang YN (2003) Occurrence characteristic of Kashin-beck disease based on nuclear family pedigrees. Acad J Xi’an jiaotong Univ l5:34-7
  
• 作者单位：Chun-xia Cao (1)
  Yin-gang Zhang (2)
  Shi-xun Wu (2)
  Mohammad Imran Younas (1)
  Xiong Guo (1)
  
  1. Faculty of Public Health, College of Medicine, Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi’an Jiaotong University, Xi’an, Shaanxi, 710061, People’s Republic of China
  2. Department of Orthopedics Surgery, The First Affiliated Hospital, College of Medicine, Xi’an Jiaotong University, Xi’an, Shaanxi, 710061, People’s Republic of China
  

文摘

We investigated the clinical features of bone and joint lesions in children with Kashin–Beck disease (KBD) and the association of these features with their parents to determine specific clinical features for diagnosing KBD. A total of 2,248 children (4 to 18?years old) and their parents were examined by stratified cluster sampling from 33 villages in six endemic counties and from six villages in a non-endemic county. We collected individual information, clinical symptoms, and radiological signs of the right hand. KBD in children and their parents was assessed using the “Diagnosis Criteria of Kashin–Beck disease in China (WS/T207-2010).-Univariate and multivariate analyses were used to examine the correlation of clinical features between parents and offspring with KBD. The rates of clinical features in children were correlated with those in parents (P-lt;-.01). The parents of child cases had higher rates of clinical features than the parents of child controls. The prevalence of radiographic alterations in the distal end of the phalanges in the parents of child cases was significantly higher than that in the parents of child controls (father, χ 2--4.83, P--.001; mother, χ 2--0.41, P--.001). The parents of child cases were more likely to be KBD cases than the parents of controls (adjusted odds ratio, 4.4-2.1). Recognizing significant correlations in clinical features between children and their parents with KBD is helpful for early clinical diagnosis and evaluation of disease severity. Some clinical features of KBD, such as radiographic alterations in the distal end of the phalanges, might be useful for diagnosing KBD.