In vitro activity of ?-lactams and quinolones against AmpC ?-lactamase-producing Escherichia coli

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• 作者：Katsutoshi Yamasaki ; Masaru Komatsu ; Koichi Shimakawa ; Kaori Satoh ; Hisaaki Nishio ; Noriyuki Sueyoshi ; Masahiro Toyokawa ; Masako Sakamoto ; Takeshi Higuchi and Yasunao Wada ; et al.
• 关键词：lactam ; Quinolone ; AmpC ; lactamase ; Escherichia coli
• 刊名：Journal of Infection and Chemotherapy
• 出版年：2005
• 出版时间：February 2005
• 年：2005
• 卷：11
• 期：1
• 页码：9-13
• 全文大小：219 KB

文摘

We studied the antimicrobial susceptibility of AmpC -lactamase-producing Escherichia coli isolates collected at ten medical institutions in the Kinki area of Japan during a 6-month period (November 2002 through April 2003). Of 2845 E. coli isolates tested, 29 (1.0 % ) showed a minimum inhibitory concentration (MIC) for cefazolin of more than 8µg/ml and were three-dimensional extract test positive. In standard inoculum susceptibility tests against these 29 strains, the MIC90s for the four carbapenems tested ranged from 0.06µg/ml to 0.5µg/ml, and these compounds were more active than the other -lactams, with meropenem being the most active. The MIC90s for -lactams, except carbapenems, ranged from 4µg/ml to 32µg/ml, with cefepime being the most active. In high inoculum susceptibility tests against these strains, the MIC90s for the four carbapenems and cefepime were 8µg/ml or less, and these compounds were more active than other -lactams. The MIC90s for -lactams, except carbapenems and cefepime, were 32µg/ml or more. The MIC90s for the five quinolones tested ranged from 4µg/ml to 16µg/ml, and the order of increasing susceptibility was ciprofloxacin > levofloxacin, gatifloxacin and pazufloxacin > prulifloxacin.