Prediction of lack of response to neoadjuvant chemotherapy in rare breast tumour histology with Tc-99m sestamibi scintimammography

详细信息    查看全文

• 作者：Ashwani Sood (1)
  Rajeev K. Seam (1)
  Kavita Mardi (2)
  Manoj K. Gupta (1)
  Sandeep Sethi (1)
  
• 关键词：Pleomorphic liposarcoma ; Locally advanced breast carcinoma ; Neoadjuvant chemotherapy ; Tc ; 99m sestamibi scintimammography
• 刊名：Annals of Nuclear Medicine
• 出版年：2011
• 出版时间：August 2011
• 年：2011
• 卷：25
• 期：7
• 页码：524-527
• 全文大小：237KB
• 参考文献：1. Jemel A, Murray T, Samuels A, Ghafoor A, Ward E, Thun MJ. Cancer statistics. CA Cancer J Clin. 2003;53:5鈥?6. CrossRef
  2. Eltahir A, Steven D, Heys MD, Andrew W, Hutcheon AW, Sarkar TK, et al. Treatment of large and locally advanced breast cancers using neoadjuvant chemotherapy. Am J Surg. 1998;175:127鈥?2. CrossRef
  3. Maini CL, Tofani A, Sciuto R, Semprebene A, Cavaliere R, Mottolese M, et al. Technetium-99m-MIBI scintigraphy in the assessment of neoadjuvant chemotherapy in breast carcinoma. J Nucl Med. 1997;38:1546鈥?0.
  4. Sciuto R, Pasqualoni R, Bergomi S, Petrilli G, Vici P, Belli F, et al. Prognostic value of 99m Tc-sestamibi washout in predicting response of locally advanced breast cancer to neoadjuvant chemotherapy. J Nucl Med. 2002;43:745鈥?1.
  5. McGregor A. Liposarcoma of the breast. Can Med Assoc J. 1960;82:781鈥?.
  6. Austin RM, Dupree W. Liposarcoma of the breast: a clinico-pathologic study of 20 cases. Hum Pathol. 1986;17:906鈥?3. CrossRef
  7. Gutman H, Pollock RE, Ross MI, Benjamin SR, Johnson DA, Janjan NA, et al. Sarcoma of the breast: implications for extent of therapy. The M.D. Anderson experience. Surgery. 1994;116:505鈥?.
  8. Keith WN, Stallard S, Brown R. Expression of MDR 1 and GST-p in human breast tumours: comparison to in vitro chemosensitivity. Br J Cancer. 1990;61:712鈥?. CrossRef
  9. Piwnica-Worms D, Chiu ML, Budding M, Kronauge JF, Kramer RA, Croop JM. Functional imaging of multidrug resistant P-glycoprotein with an organotechnitium complex. Cancer Res. 1993;53:977鈥?4.
  10. Del Vecchio S, Ciarmiello A, Pace L, Potena MI, Carriero MV, Mainolfi C, et al. In vivo detection of multidrug resistance (MDR1) pheotype by 99m Tc-sestamibi scan in untreated breast cancer. Eur J Nucl Med. 1997;24:150鈥?. CrossRef
  11. Rosen PP. Sarcoma. In: Rosen PP, editor. Rosen鈥檚 breast pathology. Philadelphia: Lippincott-Raven; 1997. p. 713鈥?.
  12. Garcia-Palazzo IE, Palazzo JP, Liu ZM, Taguchi T, Testa JR. Cytogenetic findings in a breast stromal sarcoma: application of fluorescence in situ hybridization to characterize the breakpoint regions in an 11:19 translocation. Cancer Genet Cytogenet. 1992;63:47鈥?1. CrossRef
  13. Berg JW, De Crosse JJ, Fracchia AA, Farrow J. Stromal sarcomas of the breast. Cancer. 1962;15:418鈥?4. CrossRef
  14. Tavassoli FA. Mesenchymal lesions. In: Tavassoli FA, editor. Pathology of the breast. 2nd ed. East Norwalk Conn: Appleton & Lang; 1999. p. 706鈥?.
  15. Lum YW, Jacobs L. Primary breast sarcoma. Surg Clin N Am. 2008;88:559鈥?0. CrossRef
  16. Gerlach JH, Bell DR, Karakousis C, Slocum HK, Kartner N, Rustum YM, et al. P-glycoprotein in human sarcoma: evidence for multidrug resistance. J Clin Oncol. 1987;5:1452鈥?0.
  17. Zelek L, Llombart-Cussac A, Terrier P, Pivot X, Guinebretiere JM, Le Pechouxe C, et al. Prognostic factors in primary breast sarcomas: a series of patients with long-term follow-up. J Clin Oncol. 2003;21:2583鈥?. CrossRef
  
• 作者单位：Ashwani Sood (1)
  Rajeev K. Seam (1)
  Kavita Mardi (2)
  Manoj K. Gupta (1)
  Sandeep Sethi (1)
  
  1. Nuclear Medicine Centre, Department of Radiotherapy, Indira Gandhi Medical College, Shimla, 171001, India
  2. Department of Pathology, Indira Gandhi Medical College, Shimla, 171001, India
  

文摘

The authors report a case of a 47-year-old female with a malignant lump in the right breast and ipsilateral axillary nodal involvement. She was pathologically misinterpreted as a case of ductal cell carcinoma with papillary component on fine needle aspiration cytology (FNAC) pre-operatively. On lines of the FNAC report, the patient underwent scintimammography (SMM) for prediction of treatment response based on washout pattern. The SMM revealed rapid washout of radiotracer predictive of poor responder. Despite unfavourable result seen with SMM, the patient received 4 cycles of neo-adjuvant chemotherapy (NACT). However, there was no clinical response after chemotherapy. The post-surgical histopathology revealed the actual histology to be pleomorphic liposarcoma. This case highlights that SMM has the ability to predict non-responsiveness of unusual tumour histology to standard NACT.