Relationship Between Cytokine Gene Polymorphisms and Risk of Postoperative Pneumonia with Esophageal Cancer

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• 作者：Kazuhiko Sakamoto (1)
  Masaaki Oka (1)
  Shigehumi Yoshino (1)
  Shoichi Hazama (1)
  Shigeru Takeda (1)
  Kiyoshi Yoshimura (1)
  Naoko Okayama (2)
  Yuji Hinoda (2) (3)
  
• 关键词：IL ; 10 polymorphism ; Postoperative pneumonia ; Esophagectomy
• 刊名：Journal of Gastrointestinal Surgery
• 出版年：2014
• 出版时间：July 2014
• 年：2014
• 卷：18
• 期：7
• 页码：1247-1253
• 全文大小：
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• 作者单位：Kazuhiko Sakamoto (1)
  Masaaki Oka (1)
  Shigehumi Yoshino (1)
  Shoichi Hazama (1)
  Shigeru Takeda (1)
  Kiyoshi Yoshimura (1)
  Naoko Okayama (2)
  Yuji Hinoda (2) (3)
  
  1. Department of Digestive Surgery and Surgical Oncology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi, 755-8505, Japan
  2. Division of Laboratory, Yamaguchi University Hospital, Yamaguchi, Japan
  3. Department of Oncology and Laboratory Medicine, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
  
• ISSN：1873-4626

文摘

Background We retrospectively evaluated the relationship between cytokine gene polymorphisms and development of postoperative pneumonia after esophagectomy. Methods In 120 patients who underwent esophagectomy, serum samples were obtained to measure levels of serum interleukin (IL)-6 and IL-10 at four time points (preoperatively, postoperative day (POD)0, POD1, and POD3). DNA extracted from peripheral blood in all patients was analyzed to determine polymorphisms of cytokines such as tumor necrosis factor-α -1031?T/C, IL-1β -511C/T, IL-6 -634C/G, and IL-10 -819?T/C. Results Postoperative pneumonia arose in 34 patients (28.3?%). Perioperative serum IL-10 levels were significantly higher for IL-10 -819 C/T-?C/C genotypes than for T/T genotypes (POD0 16.7?±-.84 vs. 8.54?±-.87?pg/ml, p--.0002; POD1 14.0?±-.64 vs. 8.8?±-.87?pg/ml, p--.0143; POD3 8.9?±-.67 vs. 4.4?±-.52?pg/ml, p--.0076). The frequency of the IL-10 -819?T/T genotype was significantly higher in patients with postoperative pneumonia than in patients without pneumonia (p--.0323). Multivariate analysis of factors such as sex, smoking, length of operation, field of lymph node dissection, and IL-10 polymorphism identified IL-10 polymorphism as independent predictor of postoperative pneumonia. Conclusions Patients with IL-10 -819?T/T genotype may be at high risk for postoperative pneumonia after esophagectomy.