Evaluation of 11C-choline PET/CT for primary diagnosis and staging of urothelial carcinoma of the upper urinary tract: a pilot study
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- 作者：Naoto Sassa (1)
Katsuhiko Kato (2)
Shinji Abe (3)
Shingo Iwano (4)
Shinji Ito (4)
Mitsuru Ikeda (2)
Kazuhiro Shimamoto (2)
Seiichi Yamamoto (2)
Tokunori Yamamoto (1)
Momokazu Gotoh (1)
Shinji Naganawa (4) - 关键词：11C ; Choline PET/CT ; Urothelial carcinoma ; Upper urinary tract ; Renal pelvis ; Ureter
- 刊名：European Journal of Nuclear Medicine and Molecular Imaging
- 出版年：2014
- 出版时间：December 2014
- 年：2014
- 卷：41
- 期：12
- 页码：2232-2241
- 全文大小：2,483 KB
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14. Rigatti P, Suardi N, Briganti A, Da Pozzo LF, Tutolo M, Villa L, et al. Pelvic/retroperitoneal salvage lymph node dissection for patients treated with radical prostatectomy with biochemical recurrence and nodal recurrence detected by [11C]c - 作者单位：Naoto Sassa (1)
Katsuhiko Kato (2)
Shinji Abe (3)
Shingo Iwano (4)
Shinji Ito (4)
Mitsuru Ikeda (2)
Kazuhiro Shimamoto (2)
Seiichi Yamamoto (2)
Tokunori Yamamoto (1)
Momokazu Gotoh (1)
Shinji Naganawa (4)
1. Department of Urology, Nagoya University Graduate School of Medicine, Nagoya, Japan
2. Department of Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine, 1-20 Daikominami 1-chome, Higashi-ku, Nagoya, 461-8673, Japan
3. Department of Radiological Technology, Nagoya University Hospital, Nagoya, Japan
4. Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan - ISSN：1619-7089
文摘
Purpose We conducted a pilot study to prospectively evaluate the efficacy of PET/CT with 11C-choline (choline PET/CT) for primary diagnosis and staging of urothelial carcinoma of the upper urinary tract (UUT-UC). Methods Enrolled in this study were 16 patients (9 men, 7 women; age range 51?–?3?years, mean?±?SD 69?±-0.8?years) with suspected UUT-UC. The patients were examined by choline PET/CT, and 13 underwent laparoscopic nephroureterectomy and partial cystectomy. Lymphadenectomy and chemotherapy were also performed as necessary in some of the patients. Of the 16 patients, 12 were confirmed to have UUT-UC (7 renal pelvis carcinoma and 5 ureteral carcinoma), 1 had malignant lymphoma (ureter), 1 had IgG4-related disease (ureter), and 2 had other benign diseases (ureter). Results Of the 16 study patients, 13 showed definite choline uptake in urothelial lesions, and of these, 11 had UUT-UC, 1 had malignant lymphoma, and 1 had IgG4-related disease. Three patients without choline uptake comprised one with UUT-UC and two with benign diseases. Of the 12 patients with UUT-UC, 3 had distant metastases, 2 had metastases only in the regional lymph nodes, and 7 had no metastases. Distant metastases and metastases in the regional lymph nodes showed definite choline uptake. The outcome in patients with UUT-UC, which was evaluated 592?–?,530?days after surgery, corresponded to the patient classification based on the presence or absence of metastases and locoregional or distant metastases. Choline uptake determined as SUVmax 10?min after administration was significantly higher than at 20?min in metastatic tumours of UUT-UC (p--.05), whereas there was no statistically significant difference between the SUVmax values at 10 and those at 20?min in primary tumours of UUT-UC. Conclusion This study suggests that choline PET/CT is a promising tool for the primary diagnosis and staging of UUT-UC.