Endomyocardial biopsy in a patient with hemorrhagic pheochromocytoma presenting as inverted Takotsubo cardiomyopathy

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• 作者：Kohei Iio (1) (6)
  Shunpei Sakurai (1)
  Tamon Kato (1)
  Shigeki Nishiyama (1)
  Takeki Hata (1)
  Eiichiro Mawatari (1)
  Chihiro Suzuki (1)
  Kazuhiro Takekoshi (2)
  Kayoko Higuchi (3)
  Toru Aizawa (4)
  Uichi Ikeda (5)
  
• 关键词：Pheochromocytoma ; Takotsubo cardiomyopathy ; Endomyocardial biopsy ; Shock
• 刊名：Heart and Vessels
• 出版年：2013
• 出版时间：March 2013
• 年：2013
• 卷：28
• 期：2
• 页码：255-263
• 全文大小：988 KB
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• 作者单位：Kohei Iio (1) (6)
  Shunpei Sakurai (1)
  Tamon Kato (1)
  Shigeki Nishiyama (1)
  Takeki Hata (1)
  Eiichiro Mawatari (1)
  Chihiro Suzuki (1)
  Kazuhiro Takekoshi (2)
  Kayoko Higuchi (3)
  Toru Aizawa (4)
  Uichi Ikeda (5)
  
  1. Department of Cardiology, Aizawa Hospital, 2-5-1 Honjou, Matsumoto, Nagano, 390-8510, Japan
  6. Department of Orthopedics, Hirosaki University School of Medicine, 5-Zaifu-cho, Hirosaki, Aomori, 036-8562, Japan
  2. Department of Laboratory Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8577, Japan
  3. Department of Pathology, Aizawa Hospital, 2-5-1 Honjou, Matsumoto, Nagano, 390-8510, Japan
  4. Diabetes Center, Aizawa Hospital, 2-5-1 Honjou, Matsumoto, Nagano, 390-8510, Japan
  5. Department of Cardiology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan
  
• ISSN：1615-2573

文摘

A 29-year-old female patient presented with shock and dyspnea due to heart failure and pulmonary edema. Echocardiography indicated excessive contraction limited to the left ventricular apex and akinesis of the basal and middle ventricle, which were confirmed by emergency left ventriculography. The finding was diagnostic of inverted Takotsubo cardiomyopathy. An abdominal computed tomography scan showed a tumor in the left adrenal gland with a central low-density area, and the plasma and urinary catecholamines were strikingly elevated. Taken together, these findings suggested the presence of a hemorrhagic pheochromocytoma. A myocardial biopsy in the very acute stage on the day of admission revealed neutrophilic infiltration and contraction-band necrosis, which was indistinguishable from the previously reported pathology in the acute phase of idiopathic Takotsubo cardiomyopathy without pheochromocytoma. The diagnosis of pheochromocytoma in this case was confirmed 7 weeks later by surgical removal of the left adrenal gland with massive hemorrhage at the center of the pheochromocytoma. The marked similarity of the endomyocardial pathology between this case and cases with idiopathic Takotsubo cardiomyopathy strongly points to catecholamine excess as a common causality for Takotsubo cardiomyopathy with or without pheochromocytoma.