Decreased Bronchial Eosinophilic Inflammation and Mucus Hypersecretion in Asthmatic Mice Lacking All Nitric Oxide Synthase Isoforms

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• 作者：Kentaro Akata ; Kazuhiro Yatera ; Ke-Yong Wang ; Keisuke Naito ; Takaaki Ogoshi…
• 关键词：Nitric oxide ; Nitric oxide synthase ; Eosinophilic inflammation ; Bronchial asthma
• 刊名：Lung
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：194
• 期：1
• 页码：121-124
• 全文大小：616 KB
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• 作者单位：Kentaro Akata (1)
  Kazuhiro Yatera (1)
  Ke-Yong Wang (2)
  Keisuke Naito (1)
  Takaaki Ogoshi (1)
  Shingo Noguchi (1)
  Takashi Kido (1)
  Yumiko Toyohira (3)
  Hiroaki Shimokawa (4)
  Nobuyuki Yanagihara (3)
  Masato Tsutsui (5)
  Hiroshi Mukae (1)
  
  1. Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan (UOEH), 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka, 807-8555, Japan
  2. Shared-Use Research Center, UOEH, Kitakyushu, Japan
  3. Department of Pharmacology, School of Medicine, UOEH, Kitakyushu, Japan
  4. Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
  5. Department of Pharmacology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Pneumology and Respiratory System
  
• 出版者：Springer New York
• ISSN：1432-1750

文摘

Background Asthma is characterized by airflow limitation with chronic airway inflammation, hyperresponsiveness and mucus hypersecretion. NO is generated by three nitric oxide synthase (i/n/eNOSs) isoforms, but conflicting results have been reported using asthmatic mice treated with NOSs inhibitors and NOS-knockout mice. To elucidate the authentic role of NO/NOSs in asthma, we used asthmatic mice lacking all NOSs (n/i/eNOS−/−).