Phase II trial of biweekly docetaxel, cisplatin, and 5-fluorouracil chemotherapy for advanced esophageal squamous cell carcinoma
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  • 作者:Yoshihiro Tanaka ; Kazuhiro Yoshida ; Atsuko Yamada…
  • 刊名:Cancer Chemotherapy and Pharmacology
  • 出版年:2016
  • 出版时间:June 2016
  • 年:2016
  • 卷:77
  • 期:6
  • 页码:1143-1152
  • 全文大小:431 KB
  • 刊物类别:Biomedical and Life Sciences
  • 刊物主题:Biomedicine
    Cancer Research
    Pharmacology and Toxicology
    Oncology
  • 出版者:Springer Berlin / Heidelberg
  • ISSN:1432-0843
  • 卷排序:77
文摘
The prognosis of esophageal cancer patients is still unsatisfactory. Although a docetaxel, cisplatin, and 5-Fu (DCF) regimen has been reported, it is often difficult to accomplish because of severe toxicity. Therefore, we developed a new biweekly DCF (Bi-DCF) regimen and previously reported the recommended dose in a phase I dose-escalation study. We then performed a phase II study of Bi-DCF for advanced esophageal squamous cell carcinoma (SCC). Patients with clinical stage II/III were eligible. Patients received 2 courses of chemotherapy: docetaxel 35 mg/m2 with cisplatin 40 mg/m2 on days 1 and 15 and 400 mg/m2 5-fluorouracil on days 1–5 and 15–19 every 4 weeks. After completion of the chemotherapy, patients received esophagectomy. The primary endpoint was the completion rate of protocol treatment. Thirty-two patients were enrolled. The completion rate of protocol treatment (completion of two courses of preoperative chemotherapy and R0 surgery) was 100 %. During chemotherapy, the most common grade 3 or 4 toxicities were neutropenia (31.3 %). No treatment-related death was observed, and the incidence of operative morbidity was tolerable. The overall response rate after the chemotherapy was 90.3 %. This Bi-DCF regimen was well tolerated and highly active. This trial was registered with the University Hospital Medical Information Network (No. UMIN 000014625).KeywordsChemotherapyDocetaxelCisplatin5-fluorouracilEsophageal carcinoma

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