Impact of angiographic peri-stent contrast staining (PSS) on late adverse events after sirolimus-eluting stent implantation: an observation from the multicenter j-Cypher registry PSS substudy

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• 作者：Masao Imai (1)
  Takeshi Kimura (1)
  Takeshi Morimoto (2)
  Naritatsu Saito (1)
  Hiroki Shiomi (1)
  Ren Kawaguchi (3)
  Hakuken Kan (3)
  Hiroaki Mukawa (4)
  Hiroshi Fujita (5)
  Takuo Ishise (6)
  Fujio Hayashi (7)
  Kazuya Nagao (7)
  Shunsuke Take (8)
  Hiromasa Taniguchi (8)
  Hiroki Sakamoto (9)
  Takafumi Yamane (9)
  Kinya Shirota (10)
  Hiromichi Tamekiyo (11)
  Takayuki Okamura (12)
  Koichi Kishi (13)
  Shinichirou Miyazaki (13)
  Satoshi Yamamoto (14)
  Kyohei Yamaji (15)
  Tomohiro Kawasaki (16)
  Eiji Taguchi (17)
  Hitoshi Nakajima (18)
  Ippei Kosedo (18)
  Takeshi Tada (19)
  Kazushige Kadota (19)
  Kazuaki Mitsudo (19)
  
• 关键词：Stent ; Thrombosis ; Restenosis ; Coronary artery disease
• 刊名：Cardiovascular Intervention and Therapeutics
• 出版年：2014
• 出版时间：July 2014
• 年：2014
• 卷：29
• 期：3
• 页码：226-236
• 全文大小：1,205 KB
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• 作者单位：Masao Imai (1)
  Takeshi Kimura (1)
  Takeshi Morimoto (2)
  Naritatsu Saito (1)
  Hiroki Shiomi (1)
  Ren Kawaguchi (3)
  Hakuken Kan (3)
  Hiroaki Mukawa (4)
  Hiroshi Fujita (5)
  Takuo Ishise (6)
  Fujio Hayashi (7)
  Kazuya Nagao (7)
  Shunsuke Take (8)
  Hiromasa Taniguchi (8)
  Hiroki Sakamoto (9)
  Takafumi Yamane (9)
  Kinya Shirota (10)
  Hiromichi Tamekiyo (11)
  Takayuki Okamura (12)
  Koichi Kishi (13)
  Shinichirou Miyazaki (13)
  Satoshi Yamamoto (14)
  Kyohei Yamaji (15)
  Tomohiro Kawasaki (16)
  Eiji Taguchi (17)
  Hitoshi Nakajima (18)
  Ippei Kosedo (18)
  Takeshi Tada (19)
  Kazushige Kadota (19)
  Kazuaki Mitsudo (19)
  
  1. Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, 54 Shougoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan
  2. Division of General Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
  3. Gunma Prefectural Cardiovascular Center, Maebashi, Japan
  4. Ogaki Municipal Hospital, Ogaki, Japan
  5. Kyoto Second Red Cross Hospital, Kyoto, Japan
  6. Maizuru Kyosai Hospital, Kyoto, Japan
  7. Osaka Red Cross Hospital, Osaka, Japan
  8. Saiseikai Noe Hospital, Osaka, Japan
  9. National Cerebral and Cardiovascular Center, Osaka, Japan
  10. Matsue Red Cross Hospital, Matsue, Japan
  11. Tsuchiya General Hospital, Hiroshima, Japan
  12. Yamaguchi University Hospital, Yamaguchi, Japan
  13. Tokushima Red Cross Hospital, Tokushima, Japan
  14. Chikamori Medical Group Chikamori Hospital, Kochi, Japan
  15. Kokura Memorial Hospital, Kokura, Japan
  16. Shin-Koga Hospital, Kurume, Japan
  17. Saiseikai Kumamoto Hospital, Kumamoto, Japan
  18. National Hospital Organization Kagoshima Medical Center, Kagoshima, Japan
  19. Division of Cardiology, Kurashiki Central Hospital, Okayama, Japan
  
• ISSN：1868-4297

文摘

This study sought to assess clinical significance of angiographic peri-stent contrast staining (PSS) after sirolimus-eluting stent (SES) implantation in a large multicenter study with 5-year follow-up. The j-Cypher PSS substudy is a multicenter study including 5712 patients (7838 lesions) who underwent follow-up angiographic study within 12?months after SES implantation. Late acquired PSS was observed in 184 patients (3.2?%) or 194 lesions (2.5?%). Independent risk factors of PSS were chronic total occlusion and left anterior descending artery lesion, while negative risk factors were in-stent restenosis, diabetes mellitus, ?0?years of age, and left circumflex coronary artery lesion. Cumulative incidence of definite very late stent thrombosis (VLST) at 4?years after the index follow-up angiography in lesions with PSS was significantly higher than that in lesions without PSS (5.3 versus 0.7?%, P?P?=?0.01), while late TLR for restenosis excluding those TLR procedures for VLST tended to be higher in the PSS group (9.9 versus 6.3?%; P?=?0.15). PSS found in 2.5?% of lesions within 12?months after SES implantation was associated with higher risk for subsequent VLST.