Quantitative Evaluation of PEPT1 Contribution to Oral Absorption of Cephalexin in Rats

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• 作者：Takanori Hironaka ; Shota Itokawa ; Ken-ichi Ogawara ; Kazutaka Higaki and Toshikiro Kimura
• 关键词：KEY WORDS cephalexin ; GITA model ; oral absorption ; passive diffusion ; PEPT1
• 刊名：Pharmaceutical Research
• 出版年：2009
• 出版时间：January, 2009
• 年：2009
• 卷：26
• 期：1
• 页码：40-50
• 全文大小：345.3 KB

文摘

Purpose PEPT1 mediates the intestinal absorption of many drugs, but its contribution to oral absorption of drugs is still controversial. The objective of this study is to quantitatively evaluate the contribution of PEPT1 to oral absorption of cephalexin, a typical substrate for PEPT1, in rats.