Appearance of Double Peaks in Plasma Concentration–time Profile after Oral Administration Depends on Gastric Emptying Profile and Weight Function
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- 作者：Yukiko Metsugi ; Yoshihiro Miyaji ; Ken-ichi Ogawara ; Kazutaka Higaki and Toshikiro Kimura
- 关键词：Absorption rate ; Double peaks ; Gastric emptying ; Weight function
- 刊名：Pharmaceutical Research
- 出版年：2008
- 出版时间：April, 2008
- 年：2008
- 卷：25
- 期：4
- 页码：886-895
- 全文大小：454.5 KB
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Biomedicine
Pharmacology and Toxicology
Pharmacy
Biochemistry
Medical Law
Biomedical Engineering - 出版者：Springer Netherlands
- ISSN：1573-904X
文摘
Purpose Mechanism for double-peak occurrence in plasma concentration profile after oral administration of drugs is controversial, although irregular gastric emptying would be an important factor. The objective of this study was to assess the effect of gastric emptying and a weight function, i.e. pharmacokinetics after reaching the systemic circulation, on the double-peak appearance in plasma concentration profiles.