Advances in Intraoperative Margin Assessment for Breast Cancer

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• 作者：Jane J. Keating ; Carla Fisher ; Rebecca Batiste ; Sunil Singhal
• 关键词：Breast cancer ; Breast surgery ; Margins ; Intraoperative ; Conserve breast
• 刊名：Current Surgery Reports
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：4
• 期：4
• 全文大小：890 KB
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  26.• Keating JJ, Nims S, Venegas O, Jiang J, Holt D, Kucharczuk JC, et al. Intraoperative imaging identifies thymoma margins following neoadjuvant chemotherapy. Oncotarget. 2015. doi:10.​18632/​oncotarget.​6578 . This research introduces intraoperative molecular imaging of thymomas and margin assessment. The same concepts apply for all solid tumors, and therefore is a promising and new modality for intraoperative margin assessment for breast cancer.
  27.Keating J, Tchou J, Okusanya O, Fisher C, Batiste R, Jiang J, et al. Identification of breast cancer margins using intraoperative near-infrared imaging. J Surg Oncol. 2016;. doi:10.​1002/​jso.​24167 .PubMed
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• 作者单位：Jane J. Keating (1) (3)
  Carla Fisher (1) (3)
  Rebecca Batiste (2)
  Sunil Singhal (1) (3)
  
  1. Department of Surgery, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA
  3. Center for Precision Surgery, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA
  2. Department of Pathology, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA
  
• 刊物主题：Surgery;
• 出版者：Springer US
• ISSN：2167-4817

文摘

Breast-conserving therapy including partial mastectomy and radiation is commonly performed for patients who are surgical candidates for breast cancer. Although it is as effective as mastectomy for the treatment of early breast cancer, re-excision for positive or close margins is common. This is costly, inconvenient for patients and delays initiation of adjuvant therapies. Commonly used methods for breast tumor localization and optimization of margin assessment include preoperative wire or seed localization, precise specimen orientation, specimen radiography, and cavity shaving. Unfortunately, these techniques do not assess margins on a microscopic scale in real time. Our report reviews the current and experimental techniques of intraoperative microscopic margin assessment including frozen section, cytologic imprint analysis, ultrasound, micro-CT, MarginProbe ® , near-infrared imaging, and spectroscopy.