Osteoporosis is highly prevalent in Japanese males with chronic obstructive pulmonary disease and is associated with deteriorated pulmonary function

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• 作者：Reiko Watanabe ; Takeshi Tanaka ; Keisuke Aita…
• 关键词：Chronic obstructive pulmonary disease (COPD) ; Osteoporosis ; Vertebral fracture ; Bone mineral density ; COPD assessment test (CAT)
• 刊名：Journal of Bone and Mineral Metabolism
• 出版年：2015
• 出版时间：July 2015
• 年：2015
• 卷：33
• 期：4
• 页码：392-400
• 全文大小：506 KB
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• 作者单位：Reiko Watanabe (1)
  Takeshi Tanaka (1)
  Keisuke Aita (1)
  Masaaki Hagiya (1)
  Toshiaki Homma (1)
  Kyoko Yokosuka (2)
  Hisami Yamakawa (2)
  Tsutomu Yarita (2)
  Nobuyuki Tai (1)
  Junko Hirano (1)
  Daisuke Inoue (1)
  Ryo Okazaki (1)
  
  1. Third Department of Medicine, Teikyo University Chiba Medical Center, 3426-3 Anesaki, Ichihara, Chiba, 299-0111, Japan
  2. Yarita Hospital, 899 Goi, Ichihara, Chiba, 299-0056, Japan
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Metabolic Diseases
  Orthopedics
  Internal Medicine
  
• 出版者：Springer Japan
• ISSN：1435-5604

文摘

Osteoporosis has recently been recognized as a major comorbidity in chronic obstructive pulmonary disease (COPD). We conducted a cross-sectional study in a cohort of 136 Japanese males with COPD to evaluate the prevalence of vertebral fracture (VF) and to explore its relationship with pulmonary function parameters. VFs were present in 108 (79.4?%); multiple and severe (SQ grade 2 or 3) VFs were found in 77 (56.6?%) and 25 (18.4?%), respectively. Multivariate logistic regression analyses revealed that decrease in forced expiratory volume in one second (FEV1.0)/forced vital capacity (FVC) [odds ratio (OR) 0.963, 95?% confidence interval (CI) 0.929-98, p?=?0.036] was associated with the presence of VF after adjustment for age and that FVC (OR 0.462, 95?% CI 0.220-.968, p?=?0.041) and current smoking (OR 2.992, 95?% CI 1.128-.940, p?=?0.028) were associated with VF severity (grade 2- vs. 1). We also found that FEV1.0 was the sole independent determinant of the number of VFs by stepwise multivariate linear regression (p?<?0.001). Bone mineral density (BMD) values were available in 49 subjects. Mean T scores were ?.0?±?1.2 in femoral neck, ?.4?±?1.2 in total hip and ?.1?±?1.4 in lumbar spine. Nineteen patients (38.8?%) had a BMD T score less than ?.5. BMD Z scores of all the sites showed a progressive decrease as GOLD stage of COPD advanced (p?<?0.05). Our results indicate a high prevalence of osteoporosis in Japanese male COPD patients and a strong inter-relationship between the two diseases, re-emphasizing the urgent need for appropriate intervention to maintain both bone and lung health.