Distribution of transient receptor potential cation channel subfamily V member 1-expressing nerve fibers in mouse esophagus
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- 作者：Kenjiro Matsumoto (1) (3)
Takuji Hosoya (2) (4)
Eriko Ishikawa (1)
Kimihito Tashima (1)
Kikuko Amagase (3)
Shinichi Kato (3)
Toshihiko Murayama (2)
Syunji Horie (1) - 关键词：TRPV1 ; Mouse ; Esophagus ; Spinal afferent ; Vagal afferent
- 刊名：Histochemistry and Cell Biology
- 出版年：2014
- 出版时间：December 2014
- 年：2014
- 卷：142
- 期：6
- 页码：635-644
- 全文大小：4,706 KB
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Takuji Hosoya (2) (4)
Eriko Ishikawa (1)
Kimihito Tashima (1)
Kikuko Amagase (3)
Shinichi Kato (3)
Toshihiko Murayama (2)
Syunji Horie (1)
1. Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Josai International University, 1 Gumyo, Togane, Chiba, 283-8555, Japan
3. Division of Pathological Sciences, Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Misasagi, Ymashina, Kyoto, 607-8414, Japan
2. Department of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8675, Japan
4. Research Laboratories 2, Fuji Yakuhin Co., Ltd., Saitama, Japan - ISSN：1432-119X
文摘
Transient receptor potential cation channel subfamily V member 1 (TRPV1) plays a role in esophageal function. However, the distribution of TRPV1 nerve fibers in the esophagus is currently not well understood. In the present study, we investigated the distribution of TRPV1 and neurotransmitters released from TRPV1 nerve fibers in the mouse lower esophagus. Furthermore, we investigated changes in the presence of TRPV1 in the mouse model of esophagitis. Numerous TRPV1-immunoreactive nerve fibers were seen in both the submucosal layer and myenteric plexus of the lower esophagus and colocalized with calcitonin gene-related peptide (CGRP). TRPV1 colocalized with substance P in axons in the submucosal layer and myenteric plexus. TRPV1 colocalized with neuronal nitric oxide synthase in the myenteric plexus. We observed some colocalization of CGRP with the vesicular acetylcholine (ACh) transporter, packaging of ACh into synaptic vesicles after its synthesis in terminal cytoplasm, in the submucosal layer and myenteric plexus. In the esophagitis model, the number of the TRPV1 nerve fibers did not change, but their immunoreactive intensity increased compared with sham-operated mice. Inhibitory effect of exogenous capsaicin on electrically stimulated twitch contraction significantly increased in esophagitis model compared with the effect in sham-operated mice. Overall, these results suggest that TRPV1 nerve fibers projecting to both the submucosal and muscle layer of the esophagus are extrinsic spinal and vagal afferent neurons. Furthermore, TRPV1 nerve fibers contain CGRP, substance P, nitric oxide, and ACh. Therefore, acid influx-mediated TRPV1 activation may play a role in regulating esophageal relaxation.