Nationwide surveillance of the antimicrobial susceptibility of Neisseria gonorrhoeae from male urethritis in Japan
详细信息 查看全文
- 作者：Ryoichi Hamasuna (1) (3)
Mitsuru Yasuda (1) (4)
Kiyohito Ishikawa (1) (5)
Shinya Uehara (1) (6)
Satoshi Takahashi (1) (7)
Hiroshi Hayami (1) (8)
Shingo Yamamoto (1) (9)
Tetsuro Matsumoto (1) (3)
Shinichi Minamitani (1)
Akira Watanabe (44)
Aikichi Iwamoto (44)
Kyoichi Totsuka (44)
Junichi Kadota (44)
Keisuke Sunakawa (44)
Junko Sato (44)
Hideaki Hanaki (2)
Taiji Tsukamoto (7)
Hiroshi Kiyota (10)
Shin Egawa (11)
Kazushi Tanaka (12)
Soichi Arakawa (12)
Masato Fujisawa (12)
Hiromi Kumon (6)
Kanao Kobayashi (13)
Akio Matsubara (13)
Seiji Naito (14)
Katsunori Tatsugami (14)
Shin Ito (15)
Harunori Narita (16)
Mototsugu Kanokogi (17)
Toru Sumii (18)
Kenji Ito (19)
Takahide Hosobe (20)
Shuichi Kawai (21)
Hiromi Kawano (22)
Kazuo Takayama (23)
Takamasa Yamaguchi (24)
Katsuhisa Endo (25)
Takamine Yamauchi (26)
Shinichi Maeda (27)
Mutsumasa Yoh (28)
Masanobu Horie (29)
Masayasu Ito (30)
Hirofumi Chokyu (31)
Hideari Ihara (32)
Kikuo Akiyama (33)
Satoshi Uno (34)
Koichi Monden (35)
Shinichi Kaji (36)
Hirofumi Nishimura (37)
Motoshi Kawahara (38)
Takashi Sato (39)
Takatoshi Konishi (40)
Shohei Nishi (41)
Satoshi Ishihara (42)
Masaru Yoshioka (43) - 关键词：Neisseria gonorrhoeae ; Nationwide surveillance ; Antimicrobial susceptibilities ; Japan
- 刊名：Journal of Infection and Chemotherapy
- 出版年：2013
- 出版时间：August 2013
- 年：2013
- 卷：19
- 期：4
- 页码：571-578
- 全文大小：200KB
- 参考文献：1. Surveillance of antibiotic resistance in / Neisseria gonorrhoeae in the WHO Western Pacific Region, 2006. Commun Dis Intell 2008;32(1):48-1.
2. Surveillance of antibiotic resistance in / Neisseria gonorrhoeae in the WHO Western Pacific and South East Asian Regions, 2009. Commun Dis Intell 2011;35(1):2-.
3. Yoshida S, Urabe S, Mizuguchi Y. Antibiotic sensitivity patterns of penicillinase-positive and penicillinase-negative strains of / Neisseria gonorrhoeae isolated in Fukuoka, Japan. Br J Vener Dis. 1982;58(5):305-.
4. Akasaka S, Muratani T, Yamada Y, Inatomi H, Takahashi K, Matsumoto T. Emergence of cephem- and aztreonam-high-resistant / Neisseria gonorrhoeae that does not produce beta-lactamase. J Infect Chemother. 2001;7(1):49-0. CrossRef
5. Workowski KA, Berman S. Sexually transmitted diseases treatment guidelines, 2010. MMWR Recomm Rep. 2010;59(RR-12):1-10.
6. Deguchi T, Yasuda M, Yokoi S, Ishida K, Ito M, Ishihara S, et al. Treatment of uncomplicated gonococcal urethritis by double-dosing of 200?mg cefixime at a 6-h interval. J Infect Chemother. 2003;9(1):35-. CrossRef
7. Ito M, Deguchi T, Mizutani KS, Yasuda M, Yokoi S, Ito S, et al. Emergence and spread of / Neisseria gonorrhoeae clinical isolates harboring mosaic-like structure of penicillin-binding protein 2 in Central Japan. Antimicrob Agents Chemother. 2005;49(1):137-3. CrossRef
8. Ohnishi M, Saika T, Hoshina S, Iwasaku K, Nakayama S, Watanabe H, et al. Ceftriaxone-resistant / Neisseria gonorrhoeae, Japan. Emerg Infect Dis. 2011;17(1):148-. CrossRef
9. Shigemura K, Okada H, Shirakawa T, Tanaka K, Arakawa S, Kinoshita S, et al. Susceptibilities of / Neisseria gonorrhoeae to fluoroquinolones and other antimicrobial agents in Hyogo and Osaka, Japan. Sex Transm Infect. 2004;80(2):105-. CrossRef
10. Tanaka M, Nakayama H, Notomi T, Irie S, Tsunoda Y, Okadome A, et al. Antimicrobial resistance of / Neisseria gonorrhoeae in Japan, 1993-002: continuous increasing of ciprofloxacin-resistant isolates. Int J Antimicrob Agents. 2004;24(suppl 1):S15-2. CrossRef
11. Palmer HM, Young H, Winter A, Dave J. Emergence and spread of azithromycin-resistant / Neisseria gonorrhoeae in Scotland. J Antimicrob Chemother. 2008;62(3):490-. CrossRef
12. Tanaka M, Koga Y, Nakayama H, Kanayama A, Kobayashi I, Saika T, et al. Antibiotic-resistant phenotypes and genotypes of / Neisseria gonorrhoeae isolates in Japan: identification of strain clusters with multidrug-resistant phenotypes. Sex Transm Dis. 2011;38(9):871-. CrossRef
13. Osaka K, Takakura T, Narukawa K, Takahata M, Endo K, Kiyota H, et al. Analysis of amino acid sequences of penicillin-binding protein 2 in clinical isolates of / Neisseria gonorrhoeae with reduced susceptibility to cefixime and ceftriaxone. J Infect Chemother. 2008;14(3):195-03. CrossRef
14. Takahashi S, Kurimura Y, Hashimoto J, Uehara T, Hiyama Y, Iwasawa A, et al. Antimicrobial susceptibility and penicillin-binding protein 1 and 2 mutations in / Neisseria gonorrhoeae isolated from male urethritis in Sapporo, Japan. J Infect Chemother. 2013;19:50-. CrossRef
15. Watanabe A, Yanagihara K, Matsumoto T, Kohno S, Aoki N, Oguri T, et al. Nationwide surveillance of bacterial respiratory pathogens conducted by the Surveillance Committee of Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Clinical Microbiology in 2009: general view of the pathogens-antibacterial susceptibility. J Infect Chemother. 2012;18:609-0. CrossRef
16. Ishikawa K, Matsumoto T, Yasuda M, Uehara S, Muratani T, Yagisawa M, et al. The nationwide study of bacterial pathogens associated with urinary tract infections conducted by the Japanese Society of Chemotherapy. J Infect Chemother. 2011;17(1):126-8. CrossRef
17. Clinical and Laboratory Standards Institutes. Performance standards for antimicrobial susceptibility testing: eighteenth informational supplement M100-S182008. Wayne, PA: CLSI; 2008.
18. Kamidono S, Onodera S, Kishimoto S. Guideline for diagnosis and treatment for sexually transmitted infections, 2011 (in Japanese). Jpn J Sex Transm Infect. 2011;22(1 suppl):1-63.
19. Deguchi T, Yasuda M, Maeda S. Lack of nationwide surveillance of antimicrobial resistance of / Neisseria gonorrhoeae in Japan. Ann Intern Med. 2008;149(5):363-. CrossRef
20. Nakayama S, Tribuddharat C, Prombhul S, Shimuta K, Srifuengfung S, Unemo M, et al. Molecular analyses of TEM genes and their corresponding penicillinase-producing / Neisseria gonorrhoeae isolates in Bangkok, Thailand. Antimicrob Agents Chemother. 2012;56(2):916-0. CrossRef
21. Ohnishi M, Golparian D, Shimuta K, Saika T, Hoshina S, Iwasaku K, et al. Is / Neisseria gonorrhoeae initiating a future era of untreatable gonorrhea? Detailed characterization of the first strain with high-level resistance to ceftriaxone. Antimicrob Agents Chemother. 2011;55(7):3538-5. CrossRef
22. Unemo M, Golparian D, Nicholas R, Ohnishi M, Gallay A, Sednaoui P. High-level cefixime- and ceftriaxone-resistant / Neisseria gonorrhoeae in France: novel penA mosaic allele in a successful international clone causes treatment failure. Antimicrob Agents Chemother. 2012;56(3):1273-0. CrossRef
23. Yokoi S, Deguchi T, Ozawa T, Yasuda M, Ito S, Kubota Y, et al. Threat to cefixime treatment for gonorrhea. Emerg Infect Dis. 2007;13(8):1275-.
24. Hamasuna R, Takahashi S, Uehara S, Matsumoto T. Should urologists care for the pharyngeal infection of / Neisseria gonorrhoeae or / Chlamydia trachomatis when we treat male urethritis? J Infect Chemother. 2012;18(3):410-. CrossRef
25. Muratani T, Inatomi H, Ando Y, Kawai S, Akasaka S, Matsumoto T. Single dose 1?g ceftriaxone for urogenital and pharyngeal infection caused by / Neisseria gonorrhoeae. Int J Urol. 2008;15(9):837-2. CrossRef
26. Matsumoto T, Hamasuna R, Ishikawa K, Takahashi S, Yasuda M, Hayami H, et al. Sensitivities of major causative organisms isolated from patients with acute uncomplicated cystitis against various antibacterial agents: results of subanalysis based on the presence of menopause. J Infect Chemother. 2012;18(4):597-07. CrossRef - 作者单位：Ryoichi Hamasuna (1) (3)
Mitsuru Yasuda (1) (4)
Kiyohito Ishikawa (1) (5)
Shinya Uehara (1) (6)
Satoshi Takahashi (1) (7)
Hiroshi Hayami (1) (8)
Shingo Yamamoto (1) (9)
Tetsuro Matsumoto (1) (3)
Shinichi Minamitani (1)
Akira Watanabe (44)
Aikichi Iwamoto (44)
Kyoichi Totsuka (44)
Junichi Kadota (44)
Keisuke Sunakawa (44)
Junko Sato (44)
Hideaki Hanaki (2)
Taiji Tsukamoto (7)
Hiroshi Kiyota (10)
Shin Egawa (11)
Kazushi Tanaka (12)
Soichi Arakawa (12)
Masato Fujisawa (12)
Hiromi Kumon (6)
Kanao Kobayashi (13)
Akio Matsubara (13)
Seiji Naito (14)
Katsunori Tatsugami (14)
Shin Ito (15)
Harunori Narita (16)
Mototsugu Kanokogi (17)
Toru Sumii (18)
Kenji Ito (19)
Takahide Hosobe (20)
Shuichi Kawai (21)
Hiromi Kawano (22)
Kazuo Takayama (23)
Takamasa Yamaguchi (24)
Katsuhisa Endo (25)
Takamine Yamauchi (26)
Shinichi Maeda (27)
Mutsumasa Yoh (28)
Masanobu Horie (29)
Masayasu Ito (30)
Hirofumi Chokyu (31)
Hideari Ihara (32)
Kikuo Akiyama (33)
Satoshi Uno (34)
Koichi Monden (35)
Shinichi Kaji (36)
Hirofumi Nishimura (37)
Motoshi Kawahara (38)
Takashi Sato (39)
Takatoshi Konishi (40)
Shohei Nishi (41)
Satoshi Ishihara (42)
Masaru Yoshioka (43)
1. Urogenital Sub-committee and the Surveillance Committee of Japanese Society of Chemotherapy (JSC), The Japanese Association for Infectious Diseases (JAID) and The Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan
3. Department of Urology, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyuhsu, 807-8555, Japan
4. Department of Urology, Graduate School of Medicine, Gifu University, Gifu, Japan
5. Department of Urology, School of Medicine, Fujita Health University, Nagoya, Japan
6. Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
7. Department of Urology, Sapporo Medical University School of Medicine, Sapporo, Japan
8. Blood Purification Center, Kagoshima University Hospital, Kagoshima, Japan
9. Department of Urology, Hyogo College of Medicine, Nishinomiya, Japan
44. The Surveillance Committee of JSC, JAID and JSCM, Tokyo, Japan
2. The Kitasato Institute, Tokyo, Japan
10. Department of Urology, The Jikei University Katsushika Medical Center, Tokyo, Japan
11. Department of Urology, The Jikei University School of Medicine, Tokyo, Japan
12. Department of Urology, Kobe University Graduate School of Medicine, Kobe, Japan
13. Department of Urology, Hiroshima University Institute of Biomedical and Health Sciences, Hiroshima, Japan
14. Department of Urology, Graduate School of Medicine, Kyushu University, Fukuoka, Japan
15. iClinic, Sendai, Japan
16. Narita Clinic, Nagaya, Japan
17. Kanokogi Clinic, Nishinomiya, Japan
18. Sumii Clinic, Hiroshima, Japan
19. Ito Urology Clinic, Kitakyushu, Japan
20. Hosobe Clinic, Tokyo, Japan
21. Kawai Urology Clinic, Kitakyushu, Japan
22. Kawano Urologic and Dermatologic Clinic, Fukuoka, Japan
23. Department of Urology, Takayama Hospital, Chikushino, Japan
24. Yamaguchi Dermatology and Urology Clinic, Munakata, Japan
25. Department of Urology, JR Tokyo General Hospital, Tokyo, Japan
26. Yamauchi Urological Clinic, Aichi, Japan
27. Department of Urology, Toyota Memorial Hospital, Toyota, Japan
28. Yoh Urology and Dermatology Clinic, Inazawa, Japan
29. Department of Urology, Daiyukai Daiichi Hospital, Ichinomiya, Japan
30. Gifu Urological Clinic, Gifu, Japan
31. Chokyu Tenma Clinic, Himeji, Japan
32. Ihara Clinic, Nishinomiya, Japan
33. Akiyama Urology Clinic, Nishinomiya, Japan
34. Hirajima Clinic, Okayama, Japan
35. Araki Urological Clinic, Kurashiki, Japan
36. Kaji Clinic, Fukuoka, Japan
37. Nishimura Urology Clinic, Kitakyushu, Japan
38. Kawahara Urology Clinic, Kagoshima, Japan
39. Nissin Urological Clinic, Hokkaido, Japan
40. Department of Urology, Kano Hospital, Fukuoka, Japan
41. Nishi Urology and Dermatology Clinic, Fukuoka, Japan
42. Kizawa Memorial Hospital, Minokamo, Japan
43. Yoshioka Urology Clinic, Nishinomiya, Japan
文摘
Neisseria gonorrhoeae is one of the most important pathogens causing sexually transmitted infection, and strains that are resistant to several antimicrobials are increasing. To investigate the trends of antimicrobial susceptibility among N. gonorrhoeae strains isolated from male patients with urethritis, a Japanese surveillance committee conducted the first nationwide surveillance. The urethral discharge was collected from male patients with urethritis at 51 medical facilities from April 2009 to October 2010. Of the 156 specimens, 83 N. gonorrhoeae strains were tested for susceptibility to 18 antimicrobial agents. The prevalence of β-lactamase-producing strains and chromosomally mediated resistant strains were 7.2?% and 16.5?%, respectively. None of the strains was resistant to ceftriaxone, but the minimum inhibitory concentration (MIC) of ceftriaxone for 7 strains (8.4?%) was 0.125?μg/ml. One strain was resistant to cefixime (MIC 0.5?μg/ml). The MICs of fluoroquinolones, such as ciprofloxacin, levofloxacin, and tosufloxacin, showed a bimodal distribution. The MIC of sitafloxacin was lower than those of the three fluoroquinolones listed here, and it was found that the antimicrobial activity of sitafloxacin was stronger than that of the fluoroquinolones. The MIC of azithromycin in 2 strains was 2?μg/ml, but no high-level resistance to macrolides was detected.