Childbirth and consequent atopic disease: emerging evidence on epigenetic effects based on the hygiene and EPIIC hypotheses
详细信息    查看全文
  • 作者:H. G. Dahlen ; S. Downe ; M. L. Wright ; H. P. Kennedy
  • 关键词:Epigenetics ; Birth ; Caesarean section ; Syntocinon ; Microbiome ; Antibiotics
  • 刊名:BMC Pregnancy and Childbirth
  • 出版年:2016
  • 出版时间:December 2016
  • 年:2016
  • 卷:16
  • 期:1
  • 全文大小:627 KB
  • 参考文献:1.Kitzinger S. Rediscovering Birth. London: Little Brown and Company; 2000.
    2.Jordan B. Birth in Four Cultures: a cross cultural investigation of childbirth in Yucantan, Holland, Sweden and the United States. Illinois: Waveland Press Inc.; 1993.
    3.Murphy-Lawless J. Reading Birth and Death: A History of Obstetric Thinking. Bloomington and Indianapolis: Indiana University Press; 1998.
    4.Renfrew MJ, Homer CSE, Downe S, McFadden A, Muir N, Prentice T, et al. The Lancet's Series on Midwifery Executive Summary. Lancet. 2014;2014:1–8.
    5.Van Lerberghe W, Matthews Z, Achadi E, Ancona C, Campbell J, Channon A, et al. Country experience with strengthening of health systems and deployment of midwives in countries with high maternal mortality. Lancet. 2014. 
    6.Loudon I. Maternal mortality in the past and its relevance to developing countries today. Am J Clin Nutr. 2000;72(1):241s–6s.PubMed
    7.Dahlen H, Tracy S, Tracy MB, Bisits A, Brown C, Thornton C. Rates of obstetric intervention and associated perinatal mortality and morbidity among low-risk women giving birth in private and public hospitals in NSW (2000–2008): a linked data population-based cohort study. BMJ Open. 2014;4:e004551. doi:10.​1136/​bmjopen-2013-004551 .PubMed PubMedCentral CrossRef
    8.Lavender T, Hofmeyr GJ, Neilson JP, Kingdon C, Gyte GML. Caesarean section for non-medical reasons at term. Cochrane Database of Systematic Reviews, 2012. ssue 3. Art. No.: CD004660. DOI:10.​1002/​14651858.​CD004660.​pub3 .
    9.Sreevidya S, Sathiyasekaran BWC. High caesarean rates in Madras (India): a population-based cross-sectional study. BJOG. 2003;110:106–011.PubMed CrossRef
    10.Ledger WJ, Blaser MJ. Are we using too many antibiotics during pregnancy? BJOG. 2013;120:1450–2.PubMed PubMedCentral CrossRef
    11.NSW Health. Towards Normal Birth in NSW. Sydney: NSW Health; 2010.
    12.Gibbons L, Belizán JM, Lauer JA, Betrán AP, Merialdi M, Althabe F. The Global Numbers and Costs of Additionally Needed and Unnecessary Caesarean Sections Performed per Year: Overuse as a Barrier to Universal Coverage. Geneva: World Health Organisation; 2010.
    13.ten Hoope-Bender P, de Bernis L, Campbell J, Downe S, Fauveau V, Fogstad H, et al. Improvement of maternal and newborn health through midwifery. Lancet. 2014. http://​dx.​doi.​org/​10.​1016/​S0140-6736(14)60930-2 .
    14.Bager P, Melbye M, Rostgaard K, Benn CS, Westergaard T. Mode of delivery and risk of allergic rhinitis and asthma. J Allergy Clin Immunol. 2003;111:51–56.PubMed CrossRef
    15.Hyde MJ, Mostyn A, Modi N, Kemp PR. The health implications of birth by caesarean section. Biological Reviews. 2012;87(1):229–243.PubMed CrossRef
    16.Buchanan SL, Patterson JA, Roberts CL, Morris JM, Ford JB. Trends and morbidity associated with oxytocin use in labour in nulliparas at term. ANZJOG. 2012;52(2):173–178.PubMed
    17.McAndrew F, Thompson J, Fellows L, Large A, Speed M, Renfrew MJ. Infant feeding survey 2010. In. Edited by Health andSocial Care Information Centre; 2012.
    18.Wills-Karp M, Santeliz J, Karp CL. The germless theory of allergic disease: revisiting the hygiene hypothesis. Nat Rev Immunol. 2001;1:69–75.PubMed CrossRef
    19.Dahlen HG, Kennedy HP, Anderson CM, Bella F, Clark A, Foureur M, et al. The EPIIC hypothesis: Intrapartum effects on the neonatal epigenome and consequent health outcomes. Med Hypotheses. 2013;80:656–662.PubMed PubMedCentral CrossRef
    20.Azad MB, Konya T, Maughan H, Guttman DS, Field CJ, Chari RS, et al. Gut microbiota of healthy Canadian infants: profiles by mode of delivery and infant diet at 4 months. Canadian Medical Association 2013, CMAJ 2013. DOI:10.​1503/​cmaj.​121189 .
    21.Vidal AC, Murphy SK, Murtha AP, Schildkraut JM, Soubry A, Huang Z, et al. Associations between antibiotic exposure during pregnancy, birth weight and aberrant methylation at imprinted genes among offspring. Int J Obes (Lond). 2013;37:907–13.
    22.Moshe E. Early life, the epigenome, and human health. Acta Paediatr. 2009;98:1082–4.CrossRef
    23.Clark AE, Adamian M, Taylor JY. An Overview of Epigenetics in Nursing. Nurs Clin N Am. 2013;48:649–59.CrossRef
    24.Anderson CM, Ralph JL, Johnson L, Scheett A, Wright ML, Taylor JY, et al. First Trimester Vitamin D Status and Placental Epigenomics in Preeclampsia Among Northern Plains Primiparas. Life Sciences. 2015;129:10–15.PubMed CrossRef
    25.Bomotti S, Smith JA, Zagel A, Taylor JY, Turner ST, Kardia SLR. Epigenetic Markers of Renal Function in African Americans. Nurs Res Prac. 2013;687519:1–9.CrossRef
    26.Ehrlich M, Gama-Sosa MA, Huang LH, Midgett RM, Kuo KC, McCune RA, et al. Amount and distribution of 5-methylcytosine in human DNA from different types of tissues of cells. Nucleic Acids Res. 1982;10:2709–2721.PubMed PubMedCentral CrossRef
    27.Cedar H, Bergman Y. Programming of DNA methylation patterns. Annu Rev Biochem. 2012;81:97–117.PubMed CrossRef
    28.Jones PA. Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nat Rev Genet. 2012;13(7):484–92.PubMed CrossRef
    29.Laird PW. Principles and challenges of genomewide DNA methylation analysis. Nat Rev Genet. 2010;11(3):191–203.PubMed CrossRef
    30.Boks MP, Derks EM, Weisenberger DJ, Strengman E, Janson E, Sommer IE, et al. The relationship of DNA methylation with age, gender and genotype in twins and healthy controls. PLoS One. 2009;4:e6767.PubMed PubMedCentral CrossRef
    31.Fraga MF, Ballestar E, Paz MF, Ropero S, Setien F, Ballestar ML. Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci U S A. 2005;102(30):10604–9. doi:10.​1073/​pnas.​0500398102 .PubMed PubMedCentral CrossRef
    32.Kaminsky ZA, Tang T, Wang S-C, Ptak C, Oh GHT, Wong AHC, et al. DNA methylation profiles in monozygotic and dizygotic twins. Nat Genet. 2009;41:240–5.PubMed CrossRef
    33.Petronis A. Human morbid genetics revisited: relevance of epigenetics. Trends Genet. 2001;17(3):142–6.PubMed CrossRef
    34.Martino DJ, Tulic MK, Gordon L, Hodder M, Richman TR, Metcalfe J, et al. Evidence for age-related and individual-specific changes in DNA methylation profile of mononuclear cells during early immune development in humans. Epigenetics. 2011;6:1085–94.PubMed CrossRef
    35.Fitzpatrick DR, Shirley KM, Kelso A. Cutting edge: stable epigenetic inheritance of regional IFN-gamma promoter demethylation in CD44highCD8+ T lymphocytes. J Immunol. 1999;162:5053–5057.PubMed
    36.Mikovits JA, Young HA, Vertino P, Issa JP, Pitha PM, Turcoski-Corrales S, et al. Infection with human immunodeficiency virus type 1 upregulates DNA methyltransferase, resulting in de novo methylation of the gamma interferon (IFN-gamma) promoter and subsequent downregulation of IFN-gamma production. Mol Cell Biol. 1998;18:5166–77.PubMed PubMedCentral CrossRef
    37.Tolg C, Sabha N, Cortese R, Panchal T, Ahsan A, Soliman A, et al. Uropathogenic E. coli infection provokes epigenetic downregulation of CDKN2A (p16INK4A) in uroepithelial cells. Lab Invest. 2011;91:825–36.PubMed CrossRef
    38.Olszak T, An D, Zeissig S, Vera MP, Richter J, Franke A, et al. Microbial exposure during early life has persistent effects on natural killer T cell function. Science. 2012;336:489–93.PubMed PubMedCentral CrossRef
    39.Strachan DP. Hay fever, hygiene, and household size. BMJ. 1989;299:1259–60.PubMed PubMedCentral CrossRef
    40.Strachan DP. Family size, infection and atopy: The first decade of the “hygiene hypothesis”. Thorax. 2000;55 Suppl 1:S2–10.PubMed PubMedCentral CrossRef
    41.Rook GA, Martinelli R, Brunet LR. Innate immune responses to mycobacteria and the downregulation of atopic responses. Curr Opin Allergy Clin Immunol. 2003;3(5):337–42.PubMed CrossRef
    42.Weiss ST. Asthma in early life: is the hygiene hypothesis correct? J Pediatr. 2008;84(6):475–6.CrossRef
    43.Rook GA LCA, Raison CL. Microbial ‘Old Friends’, immunoregulation and stress resilience. Evol Med Public Health. 2013;2013:46–64.PubMed PubMedCentral CrossRef
    44.Rautava S, Ruuskanen O, Ouwehand A, Salminen S, Isolauri E. The Hygiene Hypothesis of Atopic Disease—An Extended Version. Journal of Pediatric Gastroenterology and Nutrition. 2001;38:378–88.CrossRef
    45.Blaser MJ, Falkow S. What are the consequences of the disappearing human microbiota? Nat Rev Microbiol. 2009;7:887–894. doi:10.​1038/​nrmicro2245 .
    46.Braniste V, Al-Asmakh M, Kowa C, Anuar F, Abbaspour A, Tóth M, et al. The gut microbiota influences blood
    ain barrier permeability in mice. Sci Transl Med. 2014;6(263):263ra158.
    47.Koplin J, Allen K, Gurrin L, Osborne N, Tang MLK, Dharmage S. Is caesarean delivery associated with sensitization to food allergens and IgE-mediated food allergy: A systematic review. Pediatr Allergy Immunol. 2008;19(8):682–687.PubMed CrossRef
    48.Cardwell CR, Stene LC, Joner G, Cinek O, Svensson J, Goldacre MJ, et al. Caesarean section is associated with an increased risk of childhood-onset type 1 diabetes mellitus: a meta-analysis of observational studies. Diabetologia. 2008;51:726–35.PubMed CrossRef
    49.Thavagnanam S, Fleming J, Bromley A, Shields MD, Cardwell CR. A meta-analysis of the association between Caesarean section and childhood asthma. Clin Exp Allergy. 2008;38:629–33.PubMed CrossRef
    50.Kendall AI. The bacteria of the intestinal tract of man. Science. 1915;XLll(1076):209–12.CrossRef
    51.Madan JC, Farzan SF, Hibberd PL, Karagas MR. Normal neonatal microbiome variation in relation to environmental factors, infection and allergy. Curr Opin Pediatr. 2012;24:753–759.PubMed PubMedCentral CrossRef
    52.Penders J, Thijs C, Vink C, Stelma FF, Snijders B, Kummeling I, et al. Factors influencing the composition of the intestinal microbiota in early infancy. Pediatrics. 2006;118:511–521.PubMed CrossRef
    53.Smaill FM, Gyte GM, et al. Antibiotic prophylaxis versus no prophylaxis for preventing infection after cesarean section. Cochrane Database of Systematic Reviews. 2010, CD007482. doi:10.​1002/​14651858.​CD007482.​pub2 .
    54.Costantine MM et al. Timing of perioperative antibiotics for cesarean delivery: a metaanalysis. Am J Obstet Gynecol. 2008;199(3):301. e1–6.PubMed
    55.Ohlsson, A. and V.S. Shah, Intrapartum antibiotics for known maternal Group B streptococcal colonization. Cochrane Database of Systematic Reviews, 2014. Issue 6. Art. No.: CD007467. doi: 10.​1002/​14651858.​CD007467.​pub4 .
    56.Verani JR, McGee L, Schrag SJ. Prevention of perinatal group B streptococcal disease--revised guidelines from CDC, 2010. MMWR. Recommendations and Reports : Morbidity and Mortality Weekly report. Recommendations and Reports / Centers for Disease Control. CDC. 2010;59(10):1–36.
    57.Stensballe LG, Simonsen J, Jensen SM, Bonnelykke K, Bisgaard H. Use of Antibiotics during Pregnancy Increases the Risk of Asthma in Early Childhood. J Pediatr. 2013;162(4):832-838.e833.
    58.Collier CH, Risnes K, Norwitz ER, Bracken MB, Illuzzi JL. Maternal infection in pregnancy and risk of asthma in offspring. Matern Child Health J. 2013. DOI:10.​1007/​s10995-013-1220-2 .
    59.Metsälä J, Lundqvist A, Virta LJ, Kaila M, Gissler M, Virtanen SM. Mother’s and Offspring’s Use of Antibiotics and Infant Allergy to Cow’s Milk. Epidemiology. 2013;24(2):303–309.PubMed CrossRef
    60.Ajslev TA, Andersen CS, Gamborg M, Sørensen TIA, Jess T. Childhood overweight after establishment of the gut microbiota: the role of delivery mode, pre-pregnancy weight and early administration of antibiotics. Int J Obes. 2011;35:522–529.CrossRef
    61.Goto K, Yabe K, Suzuki T, Takasuna K, Jindo T, Manabe S. Gene expression profiles in the articular cartilage of juvenile rats receiving the quinolone antibacterial agent ofloxacin. Toxicology. 2008;249:204–213.PubMed CrossRef
    62.Lamouse-Smith ES, Tzeng A, Starnbach MN. The intestinal flora is required to support antibody responses to systemic immunization in infant and germ free mice. PLoS One. 2011;6:e27662.PubMed PubMedCentral CrossRef
    63.Csoka AB, Szyf M. Epigenetic side-effects of common pharmaceuticals: A potential new field in medicine and pharmacology. Med Hypotheses. 2009;73(5):770–80.PubMed CrossRef
    64.Stokholm J, Sevelsted A, Bonnelykke K, Bisgaard H. Maternal propensity for infections and risk of childhood asthma: a registry-based cohort study. Lancet. 2014;2(8):631–637.PubMed
    65.Miller NM, Fisk NM, Modi N, Glover V. Stress responses at birth: determinants of cord arterial cortisol and links with cortisol response in infancy. BJOG. 2005;2(7):921–926.CrossRef
    66.Schlinzig T, Johansson S, Gunnar A, Ekstrom TJ, Norman M. Epigenetic modulation at birth-altered DNA-methylation in white blood cells after caesarean section. Acta Paediatr. 2009;98:1096–1099.PubMed CrossRef
    67.Almgren M, Schlinzig T, Gomez-Cabrero D, Gunnar A, Sundin M, Johansson S, et al. Cesarean delivery and hematopoietic stem cell epigenetics in the newborn infant: implications for future health? Am J Obstet Gynecol. 2014;1–7.
    68.Neumann ID. Brain oxytocin: a key regulator of emotional and social behaviours in both females and males. J Neuroendocrinol. 2008;20(6):858–65.PubMed CrossRef
    69.Provençal N, Suderman MJ, Guillemin C, Massart R, Ruggiero A, Wang D, et al: The signature of maternal rearing in the methylome in rhesus macaque prefrontal cortex and T cells. J Neurosci. 2012;32:15626–42.PubMed PubMedCentral CrossRef
    70.Szyf M. Epigenetic Mechanisms Embedding Social Experience in the Genome. In: Lowenthal Symposium. Richmond: Virginia Commonwealth University; 2014.
    71.Downe S, McCourt C. From Being to Becoming: Reconstructing childbirth knowledges. In: Downe S, editor. Normal Birth, evidence and debate. Oxford: Elsevier; 2008.
    72.Wright ML, Starkweather AR, York TP. Mechanisms of the Maternal Exposome and Implications for Health Outcomes. Advances in Nursing Science in press, (Accepted June 8, 2015).
    73.Wright RJ, Visness CM, Calatroni A, Grayson MH, Gold DR, Sandel MT, et al. Prenatal Maternal Stress and Cord Blood Innate and Adaptive Cytokine Responses in an Inner-City Cohort. Am J Respir Crit Care Med. 2010;182(1):25–33.PubMed PubMedCentral CrossRef
    74.Peters JL, Cohen S, Staudenmayer J, Hosen J, Platts-Mills TAE, Wright RJ. Prenatal negative life events increases cord blood IgE: interactions with dust mite allergen and maternal atopy. Allergy. 2012;67(4):545–551.PubMed PubMedCentral CrossRef
    75.Baron U, Floess S, Wieczorek G, Baumann K, Grützkau A, Dong J, et al. DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells. Eur J Immunol. 2007;37:2378–89.PubMed CrossRef
    76.White G, Watt P, Holt B, Holt P. Differential patterns of methylation of the IFN-Î3 promoter at CpG and non-CpG sites underlie differences in IFN-Î3 gene expression between human neonatal and adult. J Immunol. 2002;168:2820–2827.PubMed CrossRef
    77.Liu J, Ballaney M, Al-alem U, Quan C. Combined inhaled diesel exhaust particles and allergen exposure alter methylation of T helper genes and IgE production in vivo. Toxicol. 2008;102:76–81.CrossRef
    78.Bobetsis YA, Barros SP, Lin DM, Weidman JR, Dolinoy DC, Jirtle RL, et al. Bacterial infection promotes DNA hypermethylation. J Dent Res. 2007;86:169–74.PubMed CrossRef
    79.Schaub B, Liu J, Höppler S, Schleich I, Huehn J, Olek S, et al. Maternal farm exposure modulates neonatal immune mechanisms through regulatory T cells. J Allergy Clin Immunol. 2009;123:774–82.e5.
  • 作者单位:H. G. Dahlen (1)
    S. Downe (2)
    M. L. Wright (3)
    H. P. Kennedy (3)
    J. Y. Taylor (3)

    1. School of Nursing and Midwifery, Western Sydney University, Locked Bag 1797, Penrith, 2751, NSW, Australia
    2. University of Central Lancashire, Preston, PR3 2LE, Lancashire, UK
    3. Yale School of Nursing, 400 West Campus Drive, West Haven, CT, 06516, USA
  • 刊物主题:Reproductive Medicine; Maternal and Child Health; Gynecology;
  • 出版者:BioMed Central
  • ISSN:1471-2393
文摘
Background In most high and middle income countries across the world, at least 1:4 women give birth by cesarean section. Rates of labour induction and augmentation are rising steeply; and in some countries up to 50 % of laboring women and newborns are given antibiotics. Governments and international agencies are increasingly concerned about the clinical, economic and psychosocial effects of these interventions.

© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号

地址:北京市海淀区学院路29号 邮编:100083

电话:办公室:(+86 10)66554848;文献借阅、咨询服务、科技查新:66554700