Rules of co-occurring mutations characterize the antigenic evolution of human influenza A/H3N2, A/H1N1 and B viruses

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• 作者：Haifen Chen ; Xinrui Zhou ; Jie Zheng ; Chee-Keong Kwoh
• 关键词：Influenza virus ; A/H3N2/H1N1 and B ; Antigenic evolution ; Co ; occurring mutation ; Influenza vaccine
• 刊名：BMC Medical Genomics
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：9
• 期：3-supp
• 全文大小：4388KB
• 刊物主题：Human Genetics; Microarrays; Gene Expression;
• 出版者：BioMed Central
• ISSN：1755-8794
• 卷排序：9

文摘

BackgroundThe human influenza viruses undergo rapid evolution (especially in hemagglutinin (HA), a glycoprotein on the surface of the virus), which enables the virus population to constantly evade the human immune system. Therefore, the vaccine has to be updated every year to stay effective. There is a need to characterize the evolution of influenza viruses for better selection of vaccine candidates and the prediction of pandemic strains. Studies have shown that the influenza hemagglutinin evolution is driven by the simultaneous mutations at antigenic sites. Here, we analyze simultaneous or co-occurring mutations in the HA protein of human influenza A/H3N2, A/H1N1 and B viruses to predict potential mutations, characterizing the antigenic evolution.