Quantitative Assessment of the Hepatic Metabolic Volume Product in Patients with Diffuse Hepatic Steatosis and Normal Controls Through Use of FDG-PET and MR Imaging: A Novel Concept
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- 作者：Gonca G. Bural (1)
Drew A. Torigian (1)
Anne Burke (1)
Mohamed Houseni (1)
Khaled Alkhawaldeh (1)
Andrew Cucchiara (1)
Sandip Basu (1) (2)
Abass Alavi (1) - 关键词：Hepatic steatosis ; Fatty liver ; Liver ; FDG ; PET ; MRI ; Hepatic metabolic volumetric product (HMVP)
- 刊名：Molecular Imaging and Biology
- 出版年：2010
- 出版时间：June 2010
- 年：2010
- 卷：12
- 期：3
- 页码：233-239
- 全文大小：268KB
- 参考文献：1. Wanless IR, Shiota K (2004) The pathogenesis of nonalcoholic steatohepatitis and other fatty liver diseases: a four-step model including the role of lipid release and hepatic venular obstruction in the progression to cirrhosis. Semin Liver Dis 24:99-06 CrossRef
2. Lalor PF, Faint J, Aarbodem Y, Hubscher SG et al (2007) The role of cytokines and chemokines in the development of steatohepatitis. Semin Liver Dis 27:173-93 CrossRef
3. Harrison SA, Kadakia S, Lang KA et al (2002) Nonalcoholic steatohepatitis: what we know in the new millennium. Am J Gastroenterol 97:2714-724
4. McCullough AJ (2004) The clinical features, diagnosis and natural history of nonalcoholic fatty liver disease. Clin Liver Dis 8:521-33 CrossRef
5. Spahr L, Hadengue A (2005) Alcoholic and nonalcoholic steatohepatitis: the same disease! II. Management. Rev Med Suisse 7(1):2032-034
6. Saadeh S, Younossi ZM, Remer EM et al (2002) The utility of radiological imaging in nonalcoholic fatty liver disease. Gastroenterology 123:745-50 CrossRef
7. van Hoek B (2004) Non-alcoholic fatty liver disease: a brief review. Scand J Gastroenterol 241:56-9 CrossRef
8. El-Haddad G, Zhuang H, Gupta N et al (2004) Evolving role of positron emission tomography in the management of patients with inflammatory and other benign disorders. Semin Nucl Med 34:313-29 CrossRef
9. Zhuang H, Alavi A (2002) 18-fluorodeoxyglucose positron emission tomographic imaging in the detection and monitoring of infection and inflammation. Semin Nucl Med 32:47-9 CrossRef
10. Siegelman ES, Rosen MA (2001) Imaging of hepatic steatosis. Semin Liver Dis 21:71-0 CrossRef
11. Itai Y, Saida Y (2002) Pitfalls in liver imaging. Eur Radiol 12:1162-174 CrossRef
12. Mortele KJ, Ros PR (2001) Imaging of diffuse liver disease. Semin Liver Dis 21:195-12 CrossRef
13. Siegelman ES (1997) MR imaging of diffuse liver disease. Hepatic fat and iron. Magn Reson Imaging Clin N Am 5:347-65
14. Choi S, Diehl AM (2005) Role of inflammation in nonalcoholic steatohepatitis. Curr Opin Gastroenterol 21:702-07 CrossRef
15. Day CP, James OF (2005) Steatohepatitis: a tale of two “hits- Curr Opin Gastroenterol 21:702-07 CrossRef
16. Haque M, Sanyal AJ (2002) The metabolic abnormalities associated with non-alcoholic fatty liver disease. Best Pract Res Clin Gastroenterol 16:709-31 CrossRef
17. Feldstein AE, Canbay A, Angulo P et al (2003) Hepatocyte apoptosis and fas expression are prominent features of human non-alcoholic steatohepatitis. Gastroenterology 125:437-43 CrossRef
18. Feldstein AE, Werneburg NW, Canbay A et al (2004) Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway. Hepatology 40:185-94 CrossRef
19. Valenti L, Fracanzani AL, Dongiovanni P et al (2002) Tumor necrosis factor alpha promoter polymorphisms and insulin resistance in nonalcoholic fatty liver disease. Gastroenterology 122:274-80 CrossRef
20. Wigg AJ, Roberts-Thomson IC, Dymock RB et al (2001) The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor alpha in the pathogenesis of non-alcoholic steatohepatitis. Gut 48:206-11 CrossRef
21. Hui JM, Hodge A, Farrell GC et al (2004) Beyond insulin resistance in NASH: TNF-alpha or adiponectin? Hepatology 40(1):46-4 CrossRef
22. McCuskey RS, Ito Y, Robertson GR et al (2004) Hepatic microvascular dysfunction during evolution of dietary steatohepatitis in mice. Hepatology 40:386-93 CrossRef
23. Zhuang H, Yu JQ, Alavi A (2005) Applications of fluorodeoxyglucose-PET imaging in the detection of infection and inflammation and other benign disorders. Radiol Clin North Am 43:121-34 CrossRef
24. Busetto L, Tregnaghi A, De Marchi F et al (2002) Liver volume and visceral obesity in women with hepatic steatosis undergoing gastric banding. Obes Res 10:408-11 CrossRef
25. Tchelepi H, Ralls PW, Radin R, Grant E (2002) Sonography of diffuse liver disease. J Ultrasound Med 21:1023-032
26. Nomura F, Ohnishi K, Ochiai T, Okuda K (1987) Obesity-related nonalcoholic fatty liver: CT features and follow-up studies after low-calorie diet. Radiology 162:845-47
27. Fishbein MH, Gardner KG, Potter CJ et al (1997) Introduction of fast MR imaging in the assessment of hepatic steatosis. Magn Reson Imaging 15:287-93 CrossRef
28. Qayyum A, Goh JS, Kakar S et al (2005) Accuracy of liver fat quantification at MR imaging: comparison of out-of-phase gradient-echo and fat-saturated fast spin-echo techniques—initial experience. Radiology 237:507-11 CrossRef
29. Lupsor M, Badea R (2005) Imaging diagnosis and quantification of hepatic steatosis: is it an accepted alternative to needle biopsy? Rom J Gastroenterol 14:419-25
30. Chave G, Milot L, Pilleul F (2005) Out of phase magnetic resonance imaging and liver applications. J Radiol 86(9 Pt 1):993-97 CrossRef
31. Das K, Kar P (2005) Non-alcoholic steatohepatitis. J Assoc Phys India 53:195-99
32. Fishbein M, Mogren J, Mogren C et al (2005) Undetected hepatomegaly in obese children by primary care physicians: a pitfall in the diagnosis of pediatric nonalcoholic fatty liver disease. Clin Pediatr (Phila) 44:135-41 CrossRef
33. Farrell GC, Larter CZ (2006) Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology 43(2 Suppl 1):S99–S112 CrossRef
34. Yki-J?rvinen H (2005) Fat in the liver and insulin resistance. Ann Med 37:347-56 CrossRef
35. Bugianesi E, Zannoni C, Vanni E et al (2004) Non-alcoholic fatty liver and insulin resistance: a cause-effect relationship? Dig Liver Dis 36:165-73 CrossRef
36. Burke A, Lucey MR (2004) Non-alcoholic fatty liver disease, non-alcoholic steatohepatitis and orthotopic liver transplantation. Am J Transplant 4:686-93 CrossRef - 作者单位：Gonca G. Bural (1)
Drew A. Torigian (1)
Anne Burke (1)
Mohamed Houseni (1)
Khaled Alkhawaldeh (1)
Andrew Cucchiara (1)
Sandip Basu (1) (2)
Abass Alavi (1)
1. Division of Nuclear Medicine, Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, 110 Donner Bldg., Philadelphia, PA, 19104, USA
2. Radiation Medicine Centre (BARC), Tata Memorial Hospital Annexe, Parel, Bombay, 400012, India
文摘
Aims and Objectives The aim of this study was to compare hepatic standardized uptake values (SUVs) and hepatic metabolic volumetric products (HMVP) between patients of diffuse hepatic steatosis and control subjects with normal livers. Materials and Methods Twenty-seven subjects were included in the study (13 men and 14 women; age range, 34-2?years). All had 18F-2-fluoro-2-D-deoxyglucose-positron emission tomography (FDG-PET) and magnetic resonance imaging (MRI) scans with an interscan interval of 0-?months. Twelve of 27 subjects had diffuse hepatic steatosis on MRI. The remaining 15 were selected as age-matched controls based on normal liver parenchyma on MRI. Mean and maximum hepatic SUVs were calculated for both patient groups on FDG-PET images. Hepatic volumes were measured from MRI. HMVP in each subject was subsequently calculated by multiplication of hepatic volume by mean hepatic SUV. HMVPs as well as mean and maximum hepatic SUVs were compared between the two study groups. Results HMVPs, mean hepatic SUVs, and maximum hepatic SUVs were greater (statistically significant, p-lt;-.05) in subjects with diffuse hepatic steatosis compared to those in the control group. Conclusion The increase in HMVP is the result of increased hepatic metabolic activity likely related to the diffuse hepatic steatosis. The active inflammatory process related to the diffuse hepatic steatosis is the probable explanation for the increase in hepatic metabolic activity on FDG-PET study.