New promising methods of synthesis of pyridinecarbothioamides

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• 作者：N. Yu. Khromova ; S. I. Malekin ; A. V. Kutkin…
• 关键词：thioamides ; pyridinecarbothioamide ; cyanopyridine ; phosphorus pentasulfide
• 刊名：Russian Journal of General Chemistry
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：85
• 期：10
• 页码：2295-2298
• 全文大小：219 KB
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• 作者单位：N. Yu. Khromova (1)
  S. I. Malekin (1)
  A. V. Kutkin (1)
  V. B. Kondrat’ev (1)
  
  1. The State Research Center of the Russian Federation, State Research Institute of Organic Chemistry and Technology, sh. Entuziastov 23, Moscow, 111024, Russia
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Chemistry
  Russian Library of Science
  
• 出版者：MAIK Nauka/Interperiodica distributed exclusively by Springer Science+Business Media LLC.
• ISSN：1608-3350

文摘

New methods of synthesis of pyridinecarbothioamides from the corresponding cyanopyridines with the use of phosphorus pentasulfide as a thiontion agent were developed. The first method was based on the reaction of cyanopyridine with phosphorus pentasulfide in alcoholic ammonium solution followed by hydrolysis. The method provided the corresponding thioamides in 60-0% yield. The second procedure included the reaction of phosphorus pentasulfide with 4-cyanopyridine in aqueous ammonia solution, which led to the formation of pyridine-4-carbothioamides in quantitative yield. Keywords thioamides pyridinecarbothioamide cyanopyridine phosphorus pentasulfide