Synchronous unilateral triple breast cancers composed of invasive ductal carcinoma, invasive lobular carcinoma, and Paget’s disease

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• 作者：Shunsuke Onoe (1)
  Hitoshi Tsuda (1)
  Sadako Akashi-Tanaka (2)
  Takahiro Hasebe (1) (3)
  Eriko Iwamoto (2)
  Takashi Hojo (2)
  Takayuki Kinoshita (2)
  
• 关键词：Synchronous unilateral breast cancer ; Triple cancer ; Invasive lobular carcinoma ; Invasive ductal carcinoma ; Paget’s disease
• 刊名：Breast Cancer
• 出版年：2014
• 出版时间：March 2014
• 年：2014
• 卷：21
• 期：2
• 页码：241-245
• 全文大小：774 KB
• 参考文献：1. Tavassoli FA, Devilee P, editors. World Health Organization Classification of Tumours. Tumours of the breast and female genital organs. Lyon: IARC Press; 2003.
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• 作者单位：Shunsuke Onoe (1)
  Hitoshi Tsuda (1)
  Sadako Akashi-Tanaka (2)
  Takahiro Hasebe (1) (3)
  Eriko Iwamoto (2)
  Takashi Hojo (2)
  Takayuki Kinoshita (2)
  
  1. Pathology Section, Clinical Laboratory Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuoku, Tokyo, 104-0045, Japan
  2. Breast Cancer Group, Surgical Oncology Division, National Cancer Center Hospital, Tokyo, Japan
  3. Pathology Consultation Service, Clinical Trials and Practice Support Division, Center for Cancer Control and Information Section, National Cancer Center, Tokyo, Japan
  
• ISSN：1880-4233

文摘

We report a case of synchronous unilateral triple breast cancers comprising invasive ductal carcinoma (IDC), invasive lobular carcinoma (ILC), and Paget’s disease. A 57-year-old woman with a left breast mass was referred to our hospital. Mammography revealed only an isodense area with foci of microcalcification in the lateral area of the left breast. Ultrasonography revealed 2 hypoechoic masses in the outer lower and inner upper areas, and these 2 lesions were diagnosed by core needle biopsy as ILC and IDC, respectively. Left total mastectomy with sentinel lymph node biopsies was performed. In addition to the ILC and IDC, histological examination also identified Paget’s disease. Breast cancer often manifests as multiple unilateral lesions; however, it is sometimes difficult to determine whether these tumors have developed multicentrically or have multifocally invaded from an intraductal carcinoma. This case was clearly diagnosed to have occurred multicentrically because of the absence of continuity among the 3 tumors, the presence of a non-invasive component in all 3 tumors, and different histopathological findings. The synchronous unilateral development of ILCs is well known. Cases of synchronous unilateral triple or more breast cancers were reviewed, and their histopathological characteristics, including the incidence of Paget’s disease, is discussed.