Cyclin-dependent kinase inhibitors, p16 and p27, demonstrate different expression patterns in thymoma and thymic carcinoma

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• 作者：Mutsuko Omatsu (1)
  Toshiaki Kunimura (1)
  Tetsuya Mikogami (1)
  Akira Shiokawa (1)
  Atsuko Masunaga (2)
  Tomoko Nagai (3)
  Akihiko Kitami (4)
  Takashi Suzuki (4)
  Mitsutaka Kadokura (5)
  
• 关键词：Thymic carcinoma ; Thymoma ; Cyclin ; dependent kinases inhibitors ; p27 ; p16
• 刊名：General Thoracic and Cardiovascular Surgery
• 出版年：2014
• 出版时间：November 2014
• 年：2014
• 卷：62
• 期：11
• 页码：678-684
• 全文大小：1,509 KB
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• 作者单位：Mutsuko Omatsu (1)
  Toshiaki Kunimura (1)
  Tetsuya Mikogami (1)
  Akira Shiokawa (1)
  Atsuko Masunaga (2)
  Tomoko Nagai (3)
  Akihiko Kitami (4)
  Takashi Suzuki (4)
  Mitsutaka Kadokura (5)
  
  1. Department of Clinico-diagnostic Pathology, Showa University Northern Yokohama Hospital, 35-1 Chigasaki-chuo, Tsuzuki-ku, Yokohama, 224-8503, Japan
  2. Department of Clinico-diagnostic Pathology, Showa University Fujigaoka Hospital, Yokohama, Japan
  3. Department of Clinico-diagnostic Pathology, Showa University School of Medicine, Tokyo, Japan
  4. Respiratory Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan
  5. Division of Thoracic and Cardiovascular Surgery, Department of Surgery, Showa University School of Medicine, Tokyo, Japan
  
• ISSN：1863-6713

文摘

Objectives The role of cell cycle inhibitors in tumorigenesis has been proven in various neoplasms; however, their roles in thymic tumors are still unclear. We examined the expression of cell cycle inhibitors such as those of the Cip/Kip family (p21, p27, and p57) and the INK-4/ARF family (p16 and p14) in thymoma and thymic carcinoma. Methods Samples from 41 thymoma and 14 thymic carcinoma patients, and 34 normal thymic tissue samples were prepared for the study. Immunohistochemical analysis using antibodies to p21, p27, p57, p16, and p14 was carried out, and the positivity for these inhibitors in each group was estimated in terms of their subcellular location and percentage of cells showing positive staining. Results Nuclear p27 showed a stepwise decrease (p?p?p? Conclusions Our findings suggest that low nuclear and high cytoplasmic p27 expression levels, and high nuclear and cytoplasmic p16 expression levels may correlate with the increase in thymic malignancy.