Cimetidine attenuates vinorelbine-induced phlebitis in mice by militating E-selectin expression

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• 作者：Zhuo Wang (1)
  Lijuan Ma (1)
  Xuebin Wang (1)
  Heping Cai (1)
  Jin Huang (1)
  Jiyong Liu (1)
  Jinhong Hu (1)
  Dingfeng Su (2)
  
• 关键词：Cimetidine ; Vinorelbine ; Infusion ; induced phlebitis ; E ; selectin
• 刊名：Cancer Chemotherapy and Pharmacology
• 出版年：2014
• 出版时间：August 2014
• 年：2014
• 卷：74
• 期：2
• 页码：239-247
• 全文大小：749 KB
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• 作者单位：Zhuo Wang (1)
  Lijuan Ma (1)
  Xuebin Wang (1)
  Heping Cai (1)
  Jin Huang (1)
  Jiyong Liu (1)
  Jinhong Hu (1)
  Dingfeng Su (2)
  
  1. Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China
  2. Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai, 200433, China
  
• ISSN：1432-0843

文摘

Purpose We investigated E-selectin expression in mice and rabbits with vinorelbine-induced phlebitis and the effect of cimetidine. To find the relationship between E-selectin expression and vinorelbine-induced phlebitis. Methods Mouse and rabbit model of vinorelbine-induced phlebitis was established by intravenous infusion of vinorelbine. Pathological observation, molecular-biological determination of E-selectin and protein function of it was evaluated. Results Grossly, we observed swelling, edema and cord-like vessel changes in mice receiving vinorelbine but only mild edema in mice pretreated with cimetidine. Pathological scoring yielded a total score of 37 for vinorelbine-treated mice and 17 for mice pretreated with cimetidine (P?ELISA revealed that rabbits treated with vinorelbine had markedly higher serum contents of E-selectin than normal saline (NS) controls (vinorelbine 1.534?±?0.449 vs. NS 0.746?±?0.170?ng/mL, P?P?P?P?E-selectin knockout mice, we found no apparent difference in tail swelling in mice receiving vinorelbine or cimetidine and vinorelbine. Conclusions In conclusion, cimetidine attenuates vinorelbine-induced phlebitis in mice probably by suppressing increased expression of E-selectin.