Primary membranoproliferative glomerulonephritis on the decline: decreased rate from the 1970s to the 2000s in Japan

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• 作者：Tetsuya Kawamura (1)
  Joichi Usui (1)
  Koji Kaseda (1)
  Kenji Takada (4)
  Itaru Ebihara (5)
  Takashi Ishizu (6)
  Tadashi Iitsuka (7)
  Kentaro Sakai (7)
  Katsumi Takemura (8)
  Masaki Kobayashi (9)
  Akio Koyama (10)
  Katsuyoshi Kanemoto (11)
  Ryo Sumazaki (2)
  Noriko Uesugi (3)
  Masayuki Noguchi (3)
  Michio Nagata (3)
  Machi Suka (12)
  Kunihiro Yamagata (1)
  
• 关键词：Membranoproliferative glomerulonephritis ; Primary glomerular disease ; Nephrotic syndrome ; Pediatrics
• 刊名：Clinical and Experimental Nephrology
• 出版年：2013
• 出版时间：April 2013
• 年：2013
• 卷：17
• 期：2
• 页码：248-254
• 全文大小：304 KB
• 参考文献：1. Schena FP, Alpers CE. Membranoproliferative glomerulonephritis and cryogloblinemic glomerulonephritis. In: Feehally J, Floege J, Johnson RJ, editors. Comprehensive clinical nephrology. 3rd ed. Philadelphia: Mosby Elsevier; 2007. p. 243-2.
  2. Yamabe H, Johnson RJ, Gretch DR, Fukushi K, Osawa H, Miyata M, et al. Hepatitis C virus infection and membranoproliferative glomerulonephritis in Japan. J Am Soc Nephrol. 1995;6(2):220-.
  3. di Belgiojoso GB, Baroni M, Pagliari B, Lavagni MG, Porri MT, Banfi G, et al. Is membranoproliferative glomerulonephritis really decreasing? Nephron. 1985;40(3):380-. CrossRef
  4. Churg J, Bernstein J, Glassock RJ. Classification of glomerular diseases. In: Churg J, Bernstein J, Glassock RJ, editors. Renal disease. 2nd ed. New York: Igaku-Shoin; 1995. p. 1-3.
  5. Gonzalo A, Matesanz R, Teruel JL, Ortuno J. Incidence of membranoproliferative glomerulonephritis in a Spanish population. Clin Nephrol. 1986;26(3):161.
  6. Swaminathan S, Leung N, Lager DJ, Melton LJ 3rd, Bergstralh EJ, Rohlinger A, et al. Changing incidence of glomerular disease in Olmsted County, Minnesota: a 30-year renal biopsy study. Clin J Am Soc Nephrol. 2006;1:483-. CrossRef
  7. Jungers P, Forget D, Droz D, Noel LH, Grunfeld JP. Reduction in the incidence of membranoproliferative glomerulonephritis in France. Proc Eur Dial Transplant Assoc Eur Ren Assoc. 1985;22:730-.
  8. Chang JH, Kim DK, Kim HW, Park SY, Yoo T-H, Kim BS, et al. Changing prevalence of glomerular diseases in Korea adults: a review of 20?years of experience. Nephrol Dial Transplant. 2009;24(8):2406-0. CrossRef
  9. Braden GL, Mulhern JG, O’Shea MH, Nash SV, Ucci AA Jr, Germain MJ. Changing incidence of glomerular diseases in adults. Am J Kidney Dis. 2000;35(5):878-3. CrossRef
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  11. Iitaka K, Saka T, Yagisawa K, Aoki Y. Decreasing hypocomplementemia and membranoproliferative glomerulonephritis in Japan. Pediatr Nephrol. 2000;14(8-):794-. CrossRef
  12. West CD. Idiopathic membranoproliferative glomerulonephritis in childhood. Pediatr Nephrol. 1992;6(1):96-03. CrossRef
  13. Yalcinkaya F, Tumer N, Cakar N, Ekim M. Paediatric membranoproliferative glomerulonephritis is not decreasing in Turkey! Pediatr Nephrol. 1994;8(1):131-. CrossRef
  14. Bahiense-Oliveira M, Saldanha LB, Andrade Mota EL, Oliveira Penna D, Toledo Barros R, Romao-Junior JE. Primary glomerular diseases in Brazil (1979-999): is the frequency of focal and segmental glomerulosclerosis increasing? Clin Nephrol. 2004;61(2):90-.
  15. Johnson RJ, Hurtado A, Merszei J, Rodriguez-Iturbe B, Feng L. Hypothesis: dysregulation of immunologic balance resulting from hygiene and socioeconomic factors may influence the epidemiology and cause of glomerulonephritis worldwide. Am J Kidney Dis. 2003;42(3):575-1. CrossRef
  16. Ohmori M, Ishikawa N, Yoshiyama T, Uchimura K, Aoki M, Mori T. Current epidemiological trend of tuberculosis in Japan. Int J Tuberc Lung Dis. 2002;6(5):415-3.
  17. Kiyohara T, Sato T, Totsuka A, Miyamura T, Ito T, Yoneyama T. Shifting seroepidemiology of hepatitis A in Japan, 1973-003. Microbiol Immunol. 2007;51(2):185-1.
  18. Ishii A, Tsuji M, Tada I. History of Katayama disease: Schistosomiasis japonica in Katayama district, Hiroshima, Japan. Parasitol Int. 2003;52(4):313-. CrossRef
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  20. Holdsworth SR, Kitching AR, Tipping PG. Th1 and Th2 T helper subsets affect patterns of injury and outcomes in glomerulonephritis. Kidney Int. 1999;55(4):1198-16. CrossRef
  
• 作者单位：Tetsuya Kawamura (1)
  Joichi Usui (1)
  Koji Kaseda (1)
  Kenji Takada (4)
  Itaru Ebihara (5)
  Takashi Ishizu (6)
  Tadashi Iitsuka (7)
  Kentaro Sakai (7)
  Katsumi Takemura (8)
  Masaki Kobayashi (9)
  Akio Koyama (10)
  Katsuyoshi Kanemoto (11)
  Ryo Sumazaki (2)
  Noriko Uesugi (3)
  Masayuki Noguchi (3)
  Michio Nagata (3)
  Machi Suka (12)
  Kunihiro Yamagata (1)
  
  1. Department of Nephrology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, Japan
  4. Department of Nephrology, Tsukuba Gakuen Hospital, Tsukuba, Ibaraki, Japan
  5. Department of Nephrology, Mito Saiseikai General Hospital, Mito, Ibaraki, Japan
  6. Department of Nephrology, Tsukuba Central Hospital, Ushiku, Ibaraki, Japan
  7. Department of Nephrology, Ibaraki Seinan Medical Center Hospital, Sakai, Ibaraki, Japan
  8. Takemura Nephrology Clinic, Kanuma, Tochigi, Japan
  9. Department of Nephrology, Tokyo Medical University Ibaraki Medical Center, Ami, Ibaraki, Japan
  10. Department of Nephrology, Tsukuba Memorial Hospital, Tsukuba, Ibaraki, Japan
  11. Department of Pediatrics, National Hospital Organization Chiba-East-Hospital, Chiba, Chiba, Japan
  2. Department of Pediatrics, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
  3. Department of Pathology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
  12. Department of Public Health and Environmental Medicine, The Jikei University School of Medicine, Tokyo, Japan
  
• ISSN：1437-7799

文摘

Background A prolonged change in the rate of primary membranoproliferative glomerulonephritis (MPGN) was identified using a Japanese database of renal biopsies. Methods We retrospectively investigated 6,369 renal biopsies that were performed between 1976 and 2009. Primary MPGN patients were selected, and the clinical and pathological findings were examined. We also statistically analyzed the changing rate of the onset of primary MPGN according to each decade. Results Seventy-nine cases with primary MPGN (1.2?% of total biopsies) were diagnosed. The age of the patients ranged from 6-9?years (average 34.6 years). There were 24 children and 55 adults, including 37 male and 42 female patients. Thirty-six cases of primary MPGN (45.6?%) showed nephrotic syndrome- childhood and 28 adult cases. In the pathological classification of 44 samples using electron microscopy, 29 cases were MPGN type I, 1 case was MPGN type II, and 14 cases were MPGN type III. The secular change of the rate of primary MPGN onset showed a statistically significant reduction from the 1970s to the 2000s. The rate of primary MPGN onset in the child population also significantly decreased, but not in the adult population. Among the clinical parameters, disease severity and prognosis remained unchanged. Regarding treatment in recent years, steroid pulse therapy became more available but the administration of warfarin and anti-platelet drugs significantly decreased. Conclusion We concluded that the rate of total primary MPGN and that of pediatric patients with primary MPGN decreased.