Preparation of highly purified 68Ga solutions via ion exchange in hydrochloric acid–ethanol mixtures

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• 作者：A. A. Larenkov ; A. B. Bruskin ; G. E. Kodina
• 关键词：68Ga ; Ion ; exchange purification ; 68Ge/68Ga generator post ; processing ; Radiopharmaceuticals
• 刊名：Journal of Radioanalytical and Nuclear Chemistry
• 出版年：2015
• 出版时间：July 2015
• 年：2015
• 卷：305
• 期：1
• 页码：147-160
• 全文大小：1,481 KB
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• 作者单位：A. A. Larenkov (1)
  A. B. Bruskin (1)
  G. E. Kodina (1)
  
  1. Burnasyan Federal Medical Biophysical Center, Zhivopisnaya str., bld. 46, 123182, Moscow, Russia
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Nuclear Chemistry
  Physical Chemistry
  Nuclear Physics, Heavy Ions and Hadrons
  Diagnostic Radiology
  Inorganic Chemistry
  
• 出版者：Akad茅miai Kiad贸, co-published with Springer Science+Business Media B.V., Formerly Kluwer Academic
• ISSN：1588-2780

文摘

The ion-exchange behavior of 68Ga in mixed HCl–ethanol media on cation and anion exchangers was studied. The mass distribution coefficients of 68Ga on Dowex 50?W?×?8 and Dowex 1?×?8 ion-exchange resins at HCl concentrations in the range 0.1-.0?M and with ethanol volume fractions 0-0?% were determined. The dynamic characteristics of the 68Ga ion exchange in mixed HCl–ethanol solutions were studied. A process, based on the data obtained, was developed for preparing of 68Ga solutions in 0.1?M HCl with high chemical and radiochemical purity that are suitable for producing of 68Ga-radiopharmaceuticals with required quality for clinical use. The suitability of the process for the synthesis of different 68Ga-radiopharmaceuticals in routine clinical practice was demonstrated.