Zwei Gesichter von Janus

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• 作者：PD Dr. I. Shimanovich (1)
  V. Merl (1)
  D. Zillikens (1)
  J. Grabbe (1)
  C. Rose (1)
  
• 关键词：Dermatopathologie ; Koexistenz ; Lupus erythematodes ; Psoriasis ; Thalidomid ; Coexistence ; Dermatopathology ; Lupus erythematosus ; Psoriasis ; Thalidomide
• 刊名：Der Hautarzt
• 出版年：2010
• 出版时间：January 2010
• 年：2010
• 卷：61
• 期：1
• 页码：58-63
• 全文大小：611KB
• 参考文献：1. Austin LM, Ozawa M, Kikuchi T et al (1999) The majority of epidermal T cells in psoriasis vulgaris lesions can produce type 1 cytokines, interferon-gamma, interleukin-2, and tumor necrosis factor-alpha, defining TC1 (cytotoxic T lymphocyte) and TH1 effector populations: a type 1 differentiation bias is also measured in circulating blood T cells in psoriatic patients. J Invest Dermatol 113:752鈥?59 CrossRef
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  10. Zalla MJ, Muller SA (1996) The coexistence of psoriasis with lupus erythematosus and other photosensitive disorders. Acta Dermatol Venereol 76:1鈥?5
  
• 作者单位：PD Dr. I. Shimanovich (1)
  V. Merl (1)
  D. Zillikens (1)
  J. Grabbe (1)
  C. Rose (1)
  
  1. Klinik f眉r Dermatologie, Allergologie und Venerologie, Universit盲t zu L眉beck, Ratzeburger Allee 160, 23538, L眉beck, Deutschland
  
• ISSN：1432-1173

文摘

While both lupus erythematosus and psoriasis are inflammatory dermatoses characterized by scaly erythematous plaques, they are rarely confused in clinical practice. We report a woman who alternately presented with lupus erythematosus and psoriasis over 14 years but the former condition was not recognized and adequately treated. After the complete diagnosis had been established, a combination of thalidomide and acitretin resulted in a prolonged remission of both disorders. This unusual case demonstrates that coexistence of two diseases in one patient presents a diagnostic challenge that can only be met by repeated careful correlation of all clinical and histopathologic findings. It is of particular importance if these diseases require conflicting management strategies.