A complete map of potential pathogenicity markers of avian influenza virus subtype H5 predicted from 11 expressed proteins
详细信息 查看全文
- 作者：Zeeshan Khaliq ; Mikael Leijon ; Sándor Belák ; Jan Komorowski
- 关键词：Avian Influenza virus ; Pathogenicity ; Virulence ; MCFS ; Rosetta ; Rough sets
- 刊名：BMC Microbiology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：15
- 期：1
- 全文大小：1,459 KB
- 刊物主题：Microbiology; Biological Microscopy; Fungus Genetics; Parasitology; Virology; Life Sciences, general;
- 出版者：BioMed Central
- ISSN：1471-2180
文摘
Background Polybasic cleavage sites of the hemagglutinin (HA) proteins are considered to be the most important determinants indicating virulence of the avian influenza viruses (AIV). However, evidence is accumulating that these sites alone are not sufficient to establish high pathogenicity. There need to exist other sites located on the HA protein outside the cleavage site or on the other proteins expressed by AIV that contribute to the pathogenicity.