刊物主题:Microbiology; Biological Microscopy; Fungus Genetics; Parasitology; Virology; Life Sciences, general;
出版者:BioMed Central
ISSN:1471-2180
文摘
Background Polybasic cleavage sites of the hemagglutinin (HA) proteins are considered to be the most important determinants indicating virulence of the avian influenza viruses (AIV). However, evidence is accumulating that these sites alone are not sufficient to establish high pathogenicity. There need to exist other sites located on the HA protein outside the cleavage site or on the other proteins expressed by AIV that contribute to the pathogenicity.