Synthesis and antiadrenergic properties of β-substituted alcohols based on 6-hydroxymethylpyridoxine

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• 作者：R. S. Pavelyev ; R. R. Khairullina ; S. A. Koshkin…
• 关键词：Key wordspyridoxine ; 6 ; hydroxymethylpyridoxine ; epoxides ; β ; substituted alcohols ; anti ; adrenergic activity ; β ; blockers
• 刊名：Russian Chemical Bulletin
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：65
• 期：2
• 页码：519-531
• 全文大小：342 KB
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Chemistry
  Organic Chemistry
  Inorganic Chemistry
  Russian Library of Science
  
• 出版者：Springer New York
• ISSN：1573-9171
• 卷排序：65

文摘

An approach to the synthesis of epoxides based on 6-hydroxymethylpyridoxine acetals was developed. The epoxides obtained were involved in the ring opening reactions by nitrogen-, oxygen-, and sulfur-containing nucleophiles. Cytotoxicity and antiadrenergic properties of some synthesized compounds were studied on the models in situ and in vivo.