Mod(mdg4)-58.8, isoform of mod(mdg4) loci, directly interacts with MTACP1A and MTACP1B proteins of Drosophila melanogaster

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• 作者：A. K. Golovnin ; M. V. Kostyuchenko ; P. G. Georgiev…
• 刊名：Doklady Biochemistry and Biophysics
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：466
• 期：1
• 页码：5-8
• 全文大小：384 KB
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• 作者单位：A. K. Golovnin (1)
  M. V. Kostyuchenko (1)
  P. G. Georgiev (1)
  L. S. Melnikova (1)
  
  1. Institute of Gene Biology, Russian Academy of Sciences, ul. Vavilova 34/5, Moscow, 119334, Russia
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Biochemistry
  Biophysics and Biomedical Physics
  Russian Library of Science
  
• 出版者：MAIK Nauka/Interperiodica distributed exclusively by Springer Science+Business Media LLC.
• ISSN：1608-3091

文摘

As a result of experiments in yeast two-hybrid system, coimmunoprecipitation of proteins from D. melanogaster embryo cell lysate, and immunostaining, it was shown for the first time that Mod(mdg4)-58.8 protein (isoform P), a product of mod(mdg4) locus, directly interacts with mtACP1A and mtACP1B proteins. These proteins are involved in de novo biosynthesis of fatty acids in mitochondria and are required for normal gametogenesis in males and females and, possibly, for the trachea development. This result expands the understanding of the role of mod(mdg4) locus products in the regulation of life activity of the eukaryotic cell.