A case of successful cure of rectal adenocarcinoma and synchronous multiple hepatic metastases with massive biliary tumor thrombi by two-stage surgery and systemic therapy

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• 作者：Masanori Tsujie (1)
  Takao Tamura (2)
  Kotaro Kitani (1)
  Sayuri Isono (1)
  Katsuaki Sato (1)
  Koki Kimura (1)
  Mitsunori Ikeda (1)
  Mitsuru Iwama (1)
  Tsuyoshi Nakayama (1)
  Yoshinori Fujiwara (1)
  Masao Yukawa (1)
  Masahiro Watatani (1)
  Yoshio Ohta (3)
  Masatoshi Inoue (1)
  
• 关键词：Liver metastasis ; Rectal cancer ; Intrabiliary tumor thrombus
• 刊名：International Cancer Conference Journal
• 出版年：2013
• 出版时间：July 2013
• 年：2013
• 卷：2
• 期：3
• 页码：139-144
• 全文大小：782KB
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• 作者单位：Masanori Tsujie (1)
  Takao Tamura (2)
  Kotaro Kitani (1)
  Sayuri Isono (1)
  Katsuaki Sato (1)
  Koki Kimura (1)
  Mitsunori Ikeda (1)
  Mitsuru Iwama (1)
  Tsuyoshi Nakayama (1)
  Yoshinori Fujiwara (1)
  Masao Yukawa (1)
  Masahiro Watatani (1)
  Yoshio Ohta (3)
  Masatoshi Inoue (1)
  
  1. Department of Surgery, Nara Hospital, Kinki University Faculty of Medicine, Otoda-chou 1248-1, Ikoma, Nara, 630-0293, Japan
  2. Department of Medical Oncology, Nara Hospital, Kinki University Faculty of Medicine, Otoda-chou 1248-1, Ikoma, Nara, 630-0293, Japan
  3. Department of Pathology, Nara Hospital, Kinki University Faculty of Medicine, Otoda-chou 1248-1, Ikoma, Nara, 630-0293, Japan
  

文摘

A 71-year-old female presented to our hospital with recent increase in diarrhea and body weight loss. Radiologic and endoscopic examinations revealed rectal adenocarcinoma with synchronous multiple liver metastases accompanied by widespread intrabiliary tumor thrombi. After primary tumor resection, systemic treatment using 5-fluorouracil, leucovorin, and oxaliplatin (FOLFOX), 5-fluorouracil, leucovorin, and irinotecan (FOLFIRI), and panitumumab was given. The disease responded well to treatment and about two?years after rectal surgery she underwent left hemihepatectomy with removal of tumor thrombi. Histological examination showed that intrahepatic bile dusts were filled with tumor thrombi indicative of a tubular adenocarcinoma resembling rectal adenocarcinoma. No tumor invasion was observed on the surgical margins. She received 5-fluorouracil and leucovorin as adjuvant treatment for six?months, and she has not shown any evidence of recurrence for one?year after hepatectomy.