Prediction of total propofol clearance based on enzyme activities in microsomes from human kidney and liver

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• 作者：Wael S. Al-Jahdari ; Koujirou Yamamoto ; Haruhiko Hiraoka ; Katsunori Nakamura ; Fumio Goto and Ryuya Horiuchi
• 关键词：Intrinsic clearance ; Propofol glucuronidation ; Propofol oxidation ; Scale ; up
• 刊名：European Journal of Clinical Pharmacology
• 出版年：2006
• 出版时间：July 2006
• 年：2006
• 卷：62
• 期：7
• 页码：527-533
• 全文大小：179 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Pharmacology and Toxicology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1041

文摘

Objective Propofol is commonly used for anesthesia and sedation in intensive care units. Approximately 53% of injected propofol is excreted in the urine as the glucuronide and 38% as hydroxylated metabolites. Liver, kidneys and intestine are suspected as clearance tissues. We investigated the contribution of the liver and kidneys to propofol metabolism in humans using an in vitro–in vivo scale up approach.