A case of quadruple primary malignancies including breast, tongue, and thyroid cancers and osteosarcoma in a young female without karyotype abnormality

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• 作者：Junko Kousaka (1)
  Kimihito Fujii (1)
  Kyoko Yorozuya (1)
  Yukako Mouri (1)
  Miwa Yoshida (1)
  Shogo Nakano (1)
  Takashi Fukutomi (1)
  Emiko Takahashi (2)
  Toyoharu Yokoi (2)
  
• 关键词：Quadruple primary malignancies ; Breast cancer ; Young woman
• 刊名：Breast Cancer
• 出版年：2014
• 出版时间：July 2014
• 年：2014
• 卷：21
• 期：4
• 页码：500-503
• 全文大小：1,034 KB
• 参考文献：1. Nakayama H, Masuda H, Ugajin W, Nakamura Y, Akiyama K, Suzuki K, et al. Quadruple cancer including bilateral breasts, Vater’s papilla, and urinary bladder: report of a case. Surg Today. 1999;29:276-. CrossRef
  2. Yukawa N, Rino Y, Ino H, Kanari M, Saeki H, Wada S, et al. A case of quadruple cancer including laryngeal cancer, lung cancer and double colon cancer. Jpn J Coll Surg. 2006;2206:961-.
  3. Demiric U, Coskun U, Gocun PU, Gurlek B, Saka B, Ozturk B, et al. Four different malignancies in one patient: a case report. Cases J. 2010;3:53. CrossRef
  4. Noh SK, Yoon JY, Ryoo UN, Choi CH, Sung CO, Kim TJ, et al. A case report of quadruple cancer in a single patient including the breast, rectum, ovary and endometrium. J Gynecol Oncol. 2008;19:265-. CrossRef
  5. Ayhan A, Yalchin OT, Tuncer ZS, Gurgan T, Kucukali T. Synchronous primary malignancies of the female genital tract. Eur J Obstet Gynecol Reprod Biol. 1992;45:63-. CrossRef
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  8. Atasever M, Yilmaz B, Dilek G, Akcay EY, Kelekci S. Synchronous primary carcinoma in 5 different organs of a genital tract: an unusual case and review of the literature. Int J Gynecol Cancer. 2009;19:802-. CrossRef
  9. Kersun LS, Wimmers RS, Hoot AC, Madedous AT. Second malignant neoplasms of the bladder after chemotherapy treatment for childhood acute lymphocytic leukemia. Pediatr Blood Cancer. 2004;42:289-1. CrossRef
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• 作者单位：Junko Kousaka (1)
  Kimihito Fujii (1)
  Kyoko Yorozuya (1)
  Yukako Mouri (1)
  Miwa Yoshida (1)
  Shogo Nakano (1)
  Takashi Fukutomi (1)
  Emiko Takahashi (2)
  Toyoharu Yokoi (2)
  
  1. Division of Breast and Endocrine Surgery, Department of Surgery, Aichi Medical University, 21 Yasago-Karimata, Nagakute, Aichi-gun, 480-1195, Japan
  2. Pathology Division, Aichi Medical University, 21 Yasago-Karimata, Nagakute, Aichi-gun, 480-1195, Japan
  
• ISSN：1880-4233

文摘

The patient was a 41-year-old, premenopausal woman with a chief complaint of well-circumscribed palpable, right breast mass without nipple discharge. Although she noticed the lump 3?months previously, the size of the tumor (1.1?×?0.9?cm2) had been stable. The patient’s mother suffered from gastric cancer. Her previous history of the triple different malignancies was as follows: (1) left osteosarcoma [amputation of left lower leg at 15?years old (y/o)]. After the operation, she was treated with various kinds of anticancer drugs including a total of 45?g ifosphamide and 342?g methotrexate; (2) tongue cancer (right radical neck resection; 23 y/o); and (3) thyroid cancer (right lobectomy; 40?y/o). There was no evidence of recurrence of these malignancies at the present consultation. At the time of tongue cancer operation, chromosome abnormality was investigated, but the results were normal. Physical examination showed a well-delimited, elastic-firm, mobile tumor in the central outer right breast. Regional lymph nodes were not palpable. Mammography showed a focal asymmetry in the right upper breast on the mediolateral oblique view. Ultrasonography revealed a hypoechoic mass with irregular margins. Distant metastases could not be detected by whole-body computed tomography scan. The histology of the Mammotome? (vacuum-assisted core needle biopsy) specimen revealed that this tumor was low-grade ductal carcinoma in?situ (DCIS). She underwent breast-conserving surgery with sentinel lymph node biopsy. On permanent histopathological examination, the diagnosis of the tumor was intracystic papilloma with low-grade DCIS. Surgical margin was negative, and sentinel lymph node metastases could not be observed. Estrogen and progesterone receptor (ER/PR) were strongly positive, but human epidermal growth factor receptor-2 (HER-2) overexpression was not tested because the lesion was DCIS. She has received no adjuvant therapy and is currently disease free 3?months after surgery.