Bacterial differentiation via gradual activation of global regulators

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• 作者：Ákos T. Kovács
• 关键词：Global regulator ; Sensor kinase ; Sliding ; Biofilm formation ; Sporulation ; Bacillus subtilis
• 刊名：Current Genetics
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：62
• 期：1
• 页码：125-128
• 全文大小：524 KB
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• 作者单位：Ákos T. Kovács (1)
  
  1. Terrestrial Biofilms Group, Institute of Microbiology, Friedrich Schiller University Jena, 07743, Jena, Germany
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Microbial Genetics and Genomics
  Microbiology
  Biochemistry
  Cell Biology
  Plant Sciences
  Proteomics
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0983

文摘

Bacteria have evolved to adapt to various conditions and respond to certain stress conditions. The ability to sense and efficiently reply to these environmental effects involve versatile array of sensors and global or specific regulators. Interestingly, modulation of the levels of active global regulators enables bacteria to respond to diverse signals via a single central transcriptional regulator and to activate or repress certain differentiation pathways at a spatio-temporal manner. The Gram-positive Bacillus subtilis is an ideal bacterium to study how membrane bound and cytoplasmic sensor kinases affect the level of phosphorylated global regulator, Spo0A which in response activates genes related to sliding, biofilm formation, and sporulation. In addition, other global regulators, including the two-component system DegS-DegU, modulate overlapping and complementary genes in B. subtilis related to surface colonization and biofilm formation. The intertwinement of global regulatory systems also allows the accurate modulation of differentiation pathways. Studies in the last decade enable us to get a deeper insight into the role of global regulators on the smooth transition of developmental processes in B. subtilis. Keywords Global regulator Sensor kinase Sliding Biofilm formation Sporulation Bacillus subtilis