RhEPO improves time to exhaustion by non-hematopoietic factors in humans
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- 作者：Simon Annaheim ; Matthias Jacob ; Alexander Krafft…
- 关键词：rhEPO doping ; Oxygen transport capacity ; Red blood cell volume ; Plasma volume
- 刊名：European Journal of Applied Physiology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：116
- 期：3
- 页码：623-633
- 全文大小：513 KB
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Matthias Jacob (4)
Alexander Krafft (5)
Christian Breymann (5)
Markus Rehm (4)
Urs Boutellier (1) (3) (6)
1. Exercise Physiology, Institute of Human Movement Sciences, ETH Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland
2. Laboratory for Protection and Physiology, EMPA, Swiss Federal Laboratories for Materials Science and Technology, Lerchenfeldstrasse 5, 9014, St. Gallen, Switzerland
3. Exercise Physiology, Institute of Physiology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland
4. Department of Anaesthesiology, University Hospital, Nussbaumstrasse 20, 80336, Munich, Germany
5. Division of Obstetrics, Department of Obstetrics and Gynaecology, University Hospital, 8000, Zurich, Switzerland
6. Exercise Physiology, ETH Zurich, Rychenbergstr. 49a, 8400, Winterthur, Switzerland - 刊物类别：Biomedical and Life Sciences
- 刊物主题：Biomedicine
Human Physiology
Occupational and Industrial Medicine
Sports Medicine - 出版者：Springer Berlin / Heidelberg
- ISSN：1439-6327
文摘
Purpose Erythropoietin (EPO) controls red cell volume (RCV) and plasma volume (PV). Therefore, injecting recombinant human EPO (rhEPO) increases RCV and most likely reduces PV. RhEPO-induced endurance improvements are explained by an increase in blood oxygen (O2) transport capacity, which increases maximum O2 uptake (\(\dot{V}\)O2max). However, it is debatable whether increased RCV or \(\dot{V}\)O2max are the main reasons for the prolongation of the time to exhaustion (t lim) at submaximal intensity. We hypothesized that high rhEPO doses in particular contracts PV such that the improvement in t lim is not as strong as at lower doses while \(\dot{V}\)O2max increases in a dose-dependent manner.