Evaluation of mRNA by Q-RTPCR and protein expression by AQUA of the M2 subunit of ribonucleotide reductase (RRM2) in human tumors

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• 作者：Jill Kolesar ; Wei Huang ; Jens Eickhoff ; Kristine Hahn ; Dona Alberti ; Steven Attia ; William Schelman ; Kyle Holen ; Anne Traynor and Percy Ivy ; et al.
• 关键词：Triapine? ; 3 ; Aminopyridine ; 2 ; carboxaldehyde thiosemicarbazone ; Ribonucleotide reductase ; Automated quantitative immunohistochemistry (AQUA) ; Quantitative real time PCR
• 刊名：Cancer Chemotherapy and Pharmacology
• 出版年：2009
• 出版时间：June, 2009
• 年：2009
• 卷：64
• 期：1
• 页码：79-86
• 全文大小：370.6 KB

文摘

Purpose The purpose of this study was to evaluate baseline RRM2 protein and gene expression in tumors of patients receiving 3-AP.