Heat shock protein 100 and the amastigote stage-specific A2 proteins of Leishmania donovani

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• 作者：Joachim Clos ; Linda Klaholz ; Manfred Kroemer ; Sylvia Krobitsch and Susan Lindquist
• 刊名：Medical Microbiology and Immunology
• 出版年：2001
• 出版时间：November 2001
• 年：2001
• 卷：190
• 期：1-2
• 页码：47-50
• 全文大小：195 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Medical Microbiology
  Immunology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1831

文摘

HSP100 protein in Leishmania spp. plays an important role for the survival and integrity of intracellular amastigotes. The A2 proteins of L. donovani are functionally linked to HSP100. There is evidence for an interdependence between these two proteins, which are both expressed predominantly in the amastigote stage of Leishmania donovani. Mutant strains lacking either of these proteins display very similar phenotypes, i.e. loss of virulence both in vivo and in vitro. Also, both proteins colocalise specifically to small foci within the cytoplasm of amastigotes.