Definition of Ktrans and FA Thresholds for Better Assessment of Experimental Glioma Using High-field MRI: A Feasibility Study

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• 作者：T. Engelhorn MD (1)
  M. A. Schwarz MSc (1)
  A. Hess PhD (2)
  L. Budinsky PhD (2)
  P. Pitann (1)
  I. Eyüpoglu PhD (3)
  A. Doerfler PhD (1)
  
• 关键词：Glioma ; MRI ; Dynamic contrast enhancement ; DTI
• 刊名：Clinical Neuroradiology
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：24
• 期：4
• 页码：337-345
• 全文大小：677 KB
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  17. Bennett KM, Hyde JS, Rand
• 作者单位：T. Engelhorn MD (1)
  M. A. Schwarz MSc (1)
  A. Hess PhD (2)
  L. Budinsky PhD (2)
  P. Pitann (1)
  I. Eyüpoglu PhD (3)
  A. Doerfler PhD (1)
  
  1. Department of Neuroradiology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054, Erlangen, Germany
  2. Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054, Erlangen, Germany
  3. Department of Neurosurgery, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054, Erlangen, Germany
  
• ISSN：1869-1447

文摘

Purpose To define Ktrans and fractional anisotropy (FA) thresholds in correlation to histology for improved magnetic resonance imaging (MRI) tumor assessment in an animal model of brain glioma. Methods Twelve rats underwent 4.7?T MRI at day 10 after tumor implantation. Anatomical scans (T2, T1 at 8?min after double dose contrast application) as well as dynamic contrast-enhanced (DCE) imaging with calculation of Ktrans and diffusion tensor imaging (DTI) with calculation of FA were performed. T2- and T1-derived tumor volumes were calculated and thresholds for Ktrans and FA were defined for best MRI tumor assessment correlated to histology. Results Tumor volumes were 159?±-4?mm3 (histology), 126?±-6?mm3 (T1 with contrast, r--.76), and 153?±-2?mm3 (T2, r--.84), respectively. Ktrans- and FA-derived tumor volumes were 160?±-6?mm3 (for Ktrans?3-.04?min?, r--.94), and 159?±-4?mm3 (for FA?￡-.14, r--.96), respectively. Conclusions DCE-MRI and DTI with calculation of Ktrans and FA maps allow very precise brain glioma assessment comparable to histology if established thresholds for the given tumor model are used.