Quantitative Analysis of 3D T1‐Weighted Gadolinium (Gd) DCE‐MRI with Different Repetition Times

详细信息    查看全文

• 关键词：DCE ; MRI ; T1 relaxation ; Gd concentration ; Pharmacokinetics
• 刊名：Lecture Notes in Computer Science
• 出版年：2016
• 出版时间：2016
• 年：2016
• 卷：9805
• 期：1
• 页码：259-268
• 全文大小：1,657 KB
• 参考文献：1.Tofts, P.: Quantitative MRI of the Brain: Measuring Changes Caused by Disease. Wiley, Hoboken (2005)
  2.O’Connor, J.P., Jackson, A., Parker, G.J., Jayson, G.C.: DCE-MRI biomarkers in the clinical evaluation of antiangiogenic and vascular disrupting agents. Br. J. Cancer 96, 189–195 (2007)CrossRef
  3.Sourbron, S., Ingrisch, M., Siefert, A., Reiser, M., Herrmann, K.: Quantification of cerebral blood flow, cerebral blood volume, and blood–brain-barrier leakage with DCE-MRI. Magn. Reson. Med. 62, 205–217 (2009)CrossRef
  4.Tofts, P.S.: T1-weighted DCE imaging concepts: modelling, acquisition and analysis. Signal 500, 400 (2010)
  5.Liberman, G., Louzoun, Y., Ben Bashat, D.: T-1 mapping using variable flip angle SPGR data with flip angle correction. J. Magn. Reson. Imaging 40, 171–180 (2014)CrossRef
  6.Whitcher, B., Schmid, V.J.: dcemriS4: a package for medical image analysis. R package version 0.40 (2010)
  7.Statistical Parametric Mapping. http://​www.​fil.​ion.​ucl.​ac.​uk/​spm/​
  8.Parker, G.J.: Measuring contrast agent concentration in T1-weighted dynamic contrast-enhanced MRI. In: Jackson, A., Buckley, D.L., Parker, G.J.M. (eds.) Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Oncology, pp. 69–79. Springer, Heidelberg (2005)
  9.Kanal, E., Maravilla, K., Rowley, H.: Gadolinium contrast agents for CNS imaging: current concepts and clinical evidence. Am. J. Neuroradiol. 35, 2215–2226 (2014)CrossRef
  10.Fritz-Hansen, T., Rostrup, E., Larsson, H.B., Søndergaard, L., Ring, P., Henriksen, O.: Measurement of the arterial concentration of Gd-DTPA using MRI: a step toward quantitative perfusion imaging. Magn. Reson. Med. 36, 225–231 (1996)CrossRef
  11.Cuenod, C.A., Balvay, D.: Perfusion and vascular permeability: basic concepts and measurement in DCE-CT and DCE-MRI. Diagn. Interv. Imaging 94, 1187–1204 (2013)CrossRef
  12.Pascual, B., Rockers, E., Bajaj, S., Anderson, J., Xue, Z., Karmonik, C., Masdeu, J.: Regional kinetics of [18F]AV-1451 uptake and Gadolinium concentration in young and older subjects. In: Abstract in 10th Human Amyloid Imaging, Miami, FL, p. 170, 13–15 January 2016
  
• 作者单位：Elijah D. Rockers (18)
  Maria B. Pascual (18)
  Sahil Bajaj (18)
  Joseph C. Masdeu (18)
  Zhong Xue (19)
  
  18. Department of Neurology, Nantz National Alzheimer Center, Houston Methodist Neurological Institute, Houston, USA
  19. Houston Methodist Research Institute, Weill Cornell Medicine, Houston, TX, USA
  
• 丛书名：Medical Imaging and Augmented Reality
• ISBN：978-3-319-43775-0
• 刊物类别：Computer Science
• 刊物主题：Artificial Intelligence and Robotics
  Computer Communication Networks
  Software Engineering
  Data Encryption
  Database Management
  Computation by Abstract Devices
  Algorithm Analysis and Problem Complexity
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1611-3349
• 卷排序：9805

文摘

Dynamic contrast-enhanced MRI (DCE-MRI) acquires T₁-weighted MRI scans before and after injection of an MRI contrast agent such as gadolinium (Gd). Gadolinium causes the relaxation time to decrease, resulting in higher MR image intensities after injection followed by a gradual decrease in image intensities during wash out. Gd does not pass the intact blood–brain barrier (BBB), thus its dynamics can be used to quantify pathology associated with BBB leaks. In current clinical practice, it is suggested to use the same pulse sequence for pre-injection T₁ calibration and Gd concentration calculation in the DCE image sequence based on the spoiled gradient recalled echo (SPGR) signal equation. A common method for T₁ estimation is using variable flip angle (VFA). However, when the parameters such as the repetition time (TR) for image acquisition could be tuned differently for T₁ estimation and DCE acquisition, the popular dcemriS4 software package that handles only a fixed TR often results in discrepancies in Gd concentration estimation. This paper reports a quick solution for calculating Gd concentrations when different TRs are used. First, the pre-injection T₁ map is calculated by using the Levenberg-Marquardt algorithm with VFA acquisition, then, because the TR used for DCE acquisition is different from the VFA TR, the equilibrium magnetization is updated with the TR for DCE, and the Gd concentration is calculated thereafter. In the experiments, we first simulated Gd concentration curves for different tissue types and generated the corresponding VFA and DCE image sequences and then used the proposed method to reconstruct the concentration. Comparing with the original simulated data allows us to validate the accuracy of the proposed computation. Further, we tested performance of the method by simulating different amounts of Ktrans changes in a manually selected region of interest (ROI). The results showed that the new method can estimate Gd dynamics more accurately in the case where different TRs are used and be sensitive enough to detect slight Ktrans changes in DCE-MRI.