Central corneal thickness determination in corneal edema using ultrasound pachymetry, a Scheimpflug camera, and anterior segment OCT

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• 作者：David Kuerten ; Niklas Plange…
• 关键词：Corneal edema ; Pachymetry ; Anterior segment diagnostic
• 刊名：Graefe's Archive for Clinical and Experimental Ophthalmology
• 出版年：2015
• 出版时间：July 2015
• 年：2015
• 卷：253
• 期：7
• 页码：1105-1109
• 全文大小：142 KB
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• 作者单位：David Kuerten (1)
  Niklas Plange (1)
  Eva Charlotte Koch (1)
  Antonis Koutsonas (1)
  Peter Walter (1)
  Matthias Fuest (1)
  
  1. Department of Ophthalmology, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Ophthalmology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1435-702X

文摘

Purpose The purpose of this study is to determine the influence of post-surgical corneal edema on the reliability and reproducibility of central corneal thickness (CCT) measurements by a Scheimpflug camera (Pentacam), ultrasound pachymetry (USP), and anterior-segment spectral-domain optical coherence tomography (AS-OCT). Methods Thirty-two patients planned for cataract surgery (n--6) or vitrectomy (n-??) were included in a prospective study. The non-surgery eye was used as control. Two investigators acquired two measurements each, with the Pentacam (Oculus, Germany) and the AS-OCT (Heidelberg Engineering, Germany) in a randomized order, followed by USP (Tomey SP-100, Germany). CCT was evaluated using the apex value for Pentacam, the corneal apex cut in AS–OCT and averaging eight single measurements for USP. Coefficients of variation (COV) and intra-class correlation coefficients (ICC) were determined. Results Post-surgery corneas showed a thickness of (investigators 1 and 2): Pentacam (615.9?±-8.02?μm and 615.1?±-0.17?μm), USP (601.4?±-3.77?μm and 614.5?±-0.91?μm), AS-OCT (608.8?±-5.67?μm and 606.9?±-4.41?μm) ,with no significant difference (ANOVA p-gt;-.99). The COVs (investigators 1 and 2) for control eyes were: Pentacam (0.78?±-.52 and 0.70?±-.76), USP (0.66?±-.29 and 0.98?±-.44), AS-OCT (0.59?±-.61 and 0.59?±-.40). The COVs (investigators 1 and 2) for post-surgical eyes were: Pentacam (0.98?±-.25 and 0.97?±-.73), USP (0.73?±-.64 and 1.35?±-.85), AS-OCT (1.34?±-.57 and 1.19?±-.18).The ICC was determined in post-surgery corneas (ICC-gt;-.96) and control corneas (ICC >?0.95). Conclusion USP measurements have the highest user dependence. Post-surgical corneal edema leads to higher intraobserver variability. All methods reached a high level of agreement in CCT determination in edematous as well as healthy corneas.