Dose reduction in dynamic CT stress myocardial perfusion imaging: comparison of 80-kV/370-mAs and 100-kV/300-mAs protocols

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• 作者：Makiko Fujita (1)
  Kakuya Kitagawa (1)
  Tatsuro Ito (1)
  Yasuyuki Shiraishi (1)
  Yusuke Kurobe (1)
  Motonori Nagata (1)
  Masaki Ishida (1)
  Hajime Sakuma (1)
  
• 关键词：Dual ; source computed tomography ; Myocardial perfusion imaging ; Image quality ; Radiation dose reduction
• 刊名：European Radiology
• 出版年：2014
• 出版时间：March 2014
• 年：2014
• 卷：24
• 期：3
• 页码：748-755
• 全文大小：476 KB
• 作者单位：Makiko Fujita (1)
  Kakuya Kitagawa (1)
  Tatsuro Ito (1)
  Yasuyuki Shiraishi (1)
  Yusuke Kurobe (1)
  Motonori Nagata (1)
  Masaki Ishida (1)
  Hajime Sakuma (1)
  
  1. Department of Radiology, Mie University School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan
  
• ISSN：1432-1084

文摘

Objectives To determine the effect of reduced 80-kV tube voltage with increased 370-mAs tube current on radiation dose, image quality and estimated myocardial blood flow (MBF) of dynamic CT stress myocardial perfusion imaging (CTP) in patients with a normal body mass index (BMI) compared with a 100-kV and 300-mAs protocol. Methods Thirty patients with a normal BMI (<25?kg/m2) with known or suspected coronary artery disease underwent adenosine-stress dual-source dynamic CTP. Patients were randomised to 80-kV/370-mAs (n--5) or 100-kV/300-mAs (n--5) imaging. Maximal enhancement and noise of the left ventricular (LV) cavity, contrast-to-noise ratio (CNR) and MBF of the two groups were compared. Results Imaging with 80-kV/370-mAs instead of 100-kV/300-mAs was associated with 40?% lower radiation dose (mean dose–length product, 359?±-6 vs 628?±-12?mGy?cm; P-lt;-.001 ) with no significant difference in CNR (34.5?±-3.4 vs 33.5?±-0.4; P--.81) or MBF in non-ischaemic myocardium (0.95?±-.20 vs 0.99?±-.25?ml/min/g; P--.66). Studies obtained using 80-kV/370-mAs were associated with 30.9?% higher maximal enhancement (804?±-04 vs 614?±-15 HU; P-lt;-.005), and 31.2?% greater noise (22.7?±-.5 vs 17.4?±-.6; P-lt;-.001). Conclusions Dynamic CTP using 80-kV/370-mA instead of 100-kV/300-mAs allowed 40?% dose reduction without compromising image quality or MBF. Tube voltage of 80-kV should be considered for individuals with a normal BMI. Key Points -CT stress perfusion imaging (CTP) is increasingly used to assess myocardial function. -Dynamic CTP is feasible at 80-kV in patients with normal BMI. -An 80-kV/370-mAs protocol allows 40?% dose reduction compared with 100-kV/300-mAs. -Contrast-to-noise ratio and myocardial blood flow of the two protocols were comparable.