文摘
Background This study was conducted to determine if patients with asymptomatic carotid artery stenosis show cognitive function decline, and if they experience any changes in cognitive function after carotid endarterectomy (CEA). Method Cognitive function was examined in 15 patients (12 males and three females, 70.0?±-.5?years) with asymptomatic carotid artery stenosis before and 3?months after CEA. Cognitive function was assessed with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), two subtests of the Wechsler Adult Intelligence Scale-Revised (WAIS-R 2 subtests), and the Japanese version of National Adult Reading Test (JART). The patients-average scores were compared with the normal average by one-sample t-tests, and the before and after scores were compared with paired t-tests. Changes in each patient were calculated from difference before and after CEA using 95?% confidence intervals. Results Before surgery, patients showed significant cognitive decline in RBANS total scale and immediate memory, language, and attention. At 3?months after CEA, the total scale and the immediate memory were not significantly different from the normal average. The average total scale score, the immediate memory and attention, and the WAIS-R 2 subtests scores were increased after treatment. Changes in each patient were calculated from the scores before and after CEA. At 3?months after CEA, the rate of increase in RBANS scores were 60.0?% of the patients for immediate memory, 26.7?% for visuospatial/constructional, 33.3?% for language and attention, 26.7?% for delayed memory, 47.7?% for total scale and 26.7?% for WAIS-R 2 subtests. Thus, so-called asymptomatic patients exhibit mild cognitive impairment before surgery, but after CEA, patients recover normal memory abilities. Conclusions Our findings of mild cognitive dysfunction in asymptomatic patients suggest that they might be symptomatic after all.