The Prognostic Importance of the Number of Metastatic Lymph Nodes for Patients Undergoing Curative Resection Followed by Adjuvant Chemoradiotherapy for Extrahepatic Bile Duct Cancer

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• 作者：Byoung Hyuck Kim ; Kyubo Kim ; Eui Kyu Chie…
• 关键词：Extrahepatic bile duct cancer ; Lymph node metastasis ; Chemoradiotherapy ; Number of metastatic lymph node
• 刊名：Journal of Gastrointestinal Surgery
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：19
• 期：10
• 页码：1833-1841
• 全文大小：518 KB
• 参考文献：1.Ganeshan D, Moron FE, Szklaruk J. Extrahepatic biliary cancer: New staging classification. World J Radiol 2012;4:345鈥?2.PubMed Central CrossRef PubMed
  2.Jung K-W, Won Y-J, Kong H-J, Oh C-M, Lee DH, Lee JS. Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2011. Cancer Res Treat 2014;46:109鈥?3.PubMed Central CrossRef PubMed
  3.Horgan AM, Amir E, Walter T, Knox JJ. Adjuvant therapy in the treatment of biliary tract cancer: a systematic review and meta-analysis. J Clin Oncol 2012;30:1934鈥?0.CrossRef PubMed
  4.Bonet Beltr谩n M, Allal AS, Gich I, Sol茅 JM, Carri贸 I. Is adjuvant radiotherapy needed after curative resection of extrahepatic biliary tract cancers? A systematic review with a meta-analysis of observational studies. Cancer Treat Rev 2012;38:111鈥?.CrossRef PubMed
  5.Aoba T, Ebata T, Yokoyama Y, Igami T, Sugawara G, Takahashi Y, Nimura Y, Nagino M. Assessment of nodal status for perihilar cholangiocarcinoma: location, number, or ratio of involved nodes. Ann Surg 2013;257:718鈥?5.CrossRef PubMed
  6.Kitagawa Y, Nagino M, Kamiya J, Uesaka K, Sano T, Yamamoto H, Hayakawa N, Nimura Y. Lymph node metastasis from hilar cholangiocarcinoma: audit of 110 patients who underwent regional and paraaortic node dissection. Ann Surg 2001;233:385鈥?2.PubMed Central CrossRef PubMed
  7.Schwarz RE, Smith DD. Lymph node dissection impact on staging and survival of extrahepatic cholangiocarcinomas, based on U.S. population data. J Gastrointest Surg 2007;11:158鈥?5.CrossRef PubMed
  8.Ito K, Ito H, Allen PJ, Gonen M, Klimstra D, D鈥橝ngelica MI, Fong Y, DeMatteo RP, Brennan MF, Blumgart LH, Jarnagin WR. Adequate lymph node assessment for extrahepatic bile duct adenocarcinoma. Ann Surg 2010;251:675鈥?1.CrossRef PubMed
  9.Kim TH, Han S-S, Park S-J, Lee WJ, Woo SM, Moon SH, Yoo T, Kim SS, Kim SH, Hong EK, Kim DY, Park J-W. Role of adjuvant chemoradiotherapy for resected extrahepatic biliary tract cancer. Int J Radiat Oncol Biol Phys 2011;81:e853鈥?.CrossRef PubMed
  10.Kim K, Chie EK, Jang J-Y, Kim SW, Han S-W, Oh D-Y, Im S-A, Kim T-Y, Bang Y-J, Ha SW. Adjuvant chemoradiotherapy after curative resection for extrahepatic bile duct cancer: a long-term single center experience. Am J Clin Oncol 2012;35:136鈥?0.CrossRef PubMed
  11.Koo TR, Eom K-Y, Kim IA, Cho JY, Yoon Y-S, Hwang DW, Han H-S, Kim J-S. Patterns of failure and prognostic factors in resected extrahepatic bile duct cancer: implication for adjuvant radiotherapy. Radiat Oncol J 2014;32:63鈥?.PubMed Central CrossRef PubMed
  12.American Joint Committee on Cancer. AJCC cancer staging manual. 7th ed. New York/London: Springer, 2011.
  13.Hakeem AR, Marangoni G, Chapman SJ, Young RS, Nair A, Hidalgo EL, Toogood GJ, Wyatt JI, Lodge PA, Prasad KR. Does the extent of lymphadenectomy, number of lymph nodes, positive lymph node ratio and neutrophil-lymphocyte ratio impact surgical outcome of perihilar cholangiocarcinoma? Eur J Gastroenterol Hepatol 2014;26:1047鈥?4.CrossRef PubMed
  14.Yeo CJ, Cameron JL, Lillemoe KD, Sohn TA, Campbell KA, Sauter PK, Coleman J, Abrams RA, Hruban RH. Pancreaticoduodenectomy with or without distal gastrectomy and extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma, part 2: randomized controlled trial evaluating survival, morbidity, and mortality. Ann Surg 2002;236:355鈥?6.PubMed Central CrossRef PubMed
  15.Kennedy EP, Yeo CJ. Pancreaticoduodenectomy with extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma. Surg Oncol Clin N Am 2007;16:157鈥?6.CrossRef PubMed
  16.Seyama Y, Kokudo N, Makuuchi M. Radical resection of biliary tract cancers and the role of extended lymphadenectomy. Surg Oncol Clin N Am 2009;18:339鈥?9, ix.CrossRef PubMed
  17.Shirai Y, Sakata J, Wakai T, Ohashi T, Ajioka Y, Hatakeyama K. Assessment of lymph node status in gallbladder cancer: location, number, or ratio of positive nodes. World J Surg Oncol 2012;10:87.PubMed Central CrossRef PubMed
  18.Sakata J, Shirai Y, Wakai T, Ajioka Y, Akazawa K, Hatakeyama K. Assessment of the nodal status in ampullary carcinoma: the number of positive lymph nodes versus the lymph node ratio. World J Surg 2011;35:2118鈥?4.CrossRef PubMed
  19.Kang HJ, Eo S-H, Kim SC, Park K-M, Lee Y-J, Lee SK, Yu E, Cho H, Hong S-M. Increased number of metastatic lymph nodes in adenocarcinoma of the ampulla of Vater as a prognostic factor: a proposal of new nodal classification. Surgery 2014;155:74鈥?4.CrossRef PubMed
  20.Esp铆n F, Bianchi A, Llorca S, Feliu J, Palomera E, Garc铆a O, Remon J, Su帽ol X. Metastatic lymph node ratio versus number of metastatic lymph nodes as a prognostic factor in gastric cancer. Eur J Surg Oncol 2012;38:497鈥?02.CrossRef PubMed
  21.Liang T-J, Wang B-W, Liu S-I, Chou N-H, Tsai C-C, Chen I-S, Yeh M-H, Chen Y-C, Chang P-M, Mok K-T. Number of involved lymph nodes is important in the prediction of prognosis for primary duodenal adenocarcinoma. J Chin Med Assoc 2012;75:573鈥?0.CrossRef PubMed
  22.Kim K, Chie EK, Jang J-Y, Kim SW, Han S-W, Oh D-Y, Im S-A, Kim T-Y, Bang Y-J, Ha SW. Prognostic Significance of Nodal Ratio in Patients Undergoing Adjuvant Chemoradiotherapy After Curative Resection for Ampullary Cancer. Am J Clin Oncol 2014;
  23.Kang MJ, Jang J-Y, Chang YR, Kwon W, Jung W, Kim S-W. Revisiting the concept of lymph node metastases of pancreatic head cancer: number of metastatic lymph nodes and lymph node ratio according to N stage. Ann Surg Oncol 2014;21:1545鈥?1.CrossRef PubMed
  24.Hong S-M, Cho H, Lee O-J, Ro JY. The number of metastatic lymph nodes in extrahepatic bile duct carcinoma as a prognostic factor. Am J Surg Pathol 2005;29:1177鈥?3.CrossRef PubMed
  25.Yoshida T, Matsumoto T, Sasaki A, Morii Y, Aramaki M, Kitano S. Prognostic factors after pancreatoduodenectomy with extended lymphadenectomy for distal bile duct cancer. Arch Surg 2002;137:69鈥?3.CrossRef PubMed
  26.Guglielmi A, Ruzzenente A, Campagnaro T, Pachera S, Conci S, Valdegamberi A, Sandri M, Iacono C. Prognostic significance of lymph node ratio after resection of peri-hilar cholangiocarcinoma. HPB 2011;13:240鈥?.PubMed Central CrossRef PubMed
  27.Oshiro Y, Sasaki R, Kobayashi A, Murata S, Fukunaga K, Kondo T, Oda T, Ohkohchi N. Prognostic relevance of the lymph node ratio in surgical patients with extrahepatic cholangiocarcinoma. Eur J Surg Oncol 2011;37:60鈥?.CrossRef PubMed
  28.Nishio H, Nagino M, Oda K, Ebata T, Arai T, Nimura Y. TNM classification for perihilar cholangiocarcinoma: comparison between 5th and 6th editions of the AJCC/UICC staging system. Langenbecks Arch Surg 2005;390:319鈥?7.CrossRef PubMed
  29.Kim K, Chie EK, Jang J-Y, Kim SW, Han S-W, Oh D-Y, Im S-A, Kim T-Y, Bang Y-J, Ha SW. Prognostic significance of tumour location after adjuvant chemoradiotherapy for periampullary adenocarcinoma. Clin Transl Oncol 2012;14:391鈥?.CrossRef PubMed
  
• 作者单位：Byoung Hyuck Kim (1)
  Kyubo Kim (1)
  Eui Kyu Chie (1)
  Jeanny Kwon (1)
  Jin-Young Jang (2)
  Sun Whe Kim (2)
  Sae-Won Han (3)
  Do-Youn Oh (3)
  Seock-Ah Im (3)
  Tae-You Kim (3)
  Yung-Jue Bang (3)
  Sung W. Ha (1)
  
  1. Department of Radiation Oncology, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Republic of Korea
  2. Department of Surgery, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Republic of Korea
  3. Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Republic of Korea
  
• 刊物主题：Surgery; Gastroenterology;
• 出版者：Springer US
• ISSN：1873-4626

文摘

Background Current nodal staging system for extrahepatic bile duct (EHBD) cancer is controversial. The number of metastatic lymph nodes (mLN) and lymph node ratio (LNR) has been studied for the assessment of the nodal status in many other gastrointestinal cancers, but there are few studies on assessing the prognostic impact of these parameters in EHBD cancer.