Carbon-based drug delivery carriers for cancer therapy

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• 作者：Dong-Jin Lim (1)
  Myeongbu Sim (3)
  Leeseul Oh (2)
  Kyunghee Lim (2)
  Hansoo Park (3)
  
• 关键词：Nanodiamonds ; Graphene oxide ; Carbon nanotube ; Drug delivery
• 刊名：Archives of Pharmacal Research
• 出版年：2014
• 出版时间：January 2014
• 年：2014
• 卷：37
• 期：1
• 页码：43-52
• 全文大小：805 KB
• 作者单位：Dong-Jin Lim (1)
  Myeongbu Sim (3)
  Leeseul Oh (2)
  Kyunghee Lim (2)
  Hansoo Park (3)
  
  1. Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, USA
  3. School of Integrative Engineering, Chung-Ang University, Heukseok-ro 84, Dongjak-gu, Seoul, 156-756, Korea
  2. School of Chemical Engineering, Chung-Ang University, Seoul, Korea
  
• ISSN：1976-3786

文摘

In the search to improve anticancer therapies, several drug carriers, including carbon-based nanomaterials have been studied. Both liposomes and polymeric microspheres have been used in anticancer drugs. However, there remains an on-going need for better therapeutic materials that have good drug solubility, an ability to reduce systemic toxicity through specific-tumor targeting, and rapid clearance. In this regard, carbon allotropes such as graphene oxide (GOs), carbon nanotubes (CNTs), and nanodiamonds (NDs), have been investigated, as they possess sufficient surface-to-volume ratio, thermal conductivity, rigid structural properties capable of post-chemical modification, and excellent biocompatibility. This review is aimed at exploring these carbon-based nanomaterials for use as multifaceted cancer drug carriers and is intended to demonstrate that GOs, CNTs, and NDs are likely to improve chemotherapeutical strategy for cancers in either a sole or combinational manner.