15N-labelled pyrazines of triterpenic acids
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- 作者：Martin Vlk ; Petra Micolova ; Milan Urban…
- 关键词：15N ; Triterpenic acid ; Isotopic labelling ; Pyrazine ; Heterobetulinic acid
- 刊名：Journal of Radioanalytical and Nuclear Chemistry
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：308
- 期：2
- 页码：733-739
- 全文大小：506 KB
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Petra Micolova (1)
Milan Urban (2) (3)
Miroslav Kvasnica (4)
David Saman (5)
Jan Sarek (2)
1. Faculty of Nuclear Sciences and Physical Engineering, Czech Technical University in Prague, Břehová 7, 115 19, Prague 1, Czech Republic
2. Faculty of Medicine and Dentistry, Institute of Molecular and Translational Medicine, Palacky University Olomouc, Hnevotinska 5, 779 00, Olomouc, Czech Republic
3. Department of Organic Chemistry, Faculty of Science, Palacky University Olomouc, 17. listopadu 1192/12, 771 46, Olomouc, Czech Republic
4. Laboratory of Growth Regulators, Centre of the Region Hana for Biotechnological and Agricultural Research, Institute of Experimental Botany ASCR & Palacky University, Slechtitelu 11, 78371, Olomouc, Czech Republic
5. Institute of Organic Chemistry and Biochemistry, ASCR, Flemingovo nam. 2, 16610, Prague 6, Czech Republic - 刊物类别：Chemistry and Materials Science
- 刊物主题：Chemistry
Nuclear Chemistry
Physical Chemistry
Nuclear Physics, Heavy Ions and Hadrons
Diagnostic Radiology
Inorganic Chemistry - 出版者：Akad茅miai Kiad贸, co-published with Springer Science+Business Media B.V., Formerly Kluwer Academic
- ISSN：1588-2780
文摘
Triterpenoid pyrazines from our research group were found selectively cytotoxic on several cancer cell lines with IC50 in low micromolar range. This sparked our interest in preparing their labeled analogs for metabolic studies. In this work, we prepared a set of non-labeled pyrazines from seven triterpenoid skeletal types along with their 15N labelled analogs. In this work, we present the synthesis and characterization of the target 15N labelled pyrazines. Currently, these compounds are being studied in complex metabolic studies.