Updated Findings of the Association and Functional Studies of DRD2/ANKK1 Variants with Addictions
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  • 作者：Yunlong Ma (1)
    Wenji Yuan (1)
    Xianzhong Jiang (1)
    Wen-Yan Cui (1)
    Ming D. Li (1) (2)

    1. State Key Laboratory for Diagnosis and Treatment of Infectious Diseases     ; The First Affiliated Hospital ; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases ; Zhejiang University School of Medicine ; Hangzhou ; China
    2. Department of Psychiatry and Neurobehavioral Sciences     ; University of Virginia ; Charlottesville ; VA ; USA
  • 关键词：ANKK1 ; Alcoholism ; DRD2 ; Functional variants ; Nicotine dependence
  • 刊名：Molecular Neurobiology
  • 出版年：2015
  • 出版时间：February 2015
  • 年：2015
  • 卷：51
  • 期：1
  • 页码：281-299
  • 全文大小：734 KB
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  • 刊物主题：Neurosciences; Neurobiology; Cell Biology; Neurology;
  • 出版者：Springer US
  • ISSN：1559-1182
文摘
Both nicotine and alcohol addictions are severe public health hazards worldwide. Various twin and family studies have demonstrated that genetic factors contribute to vulnerability to these addictions; however, the susceptibility genes and the variants underlying them remain largely unknown. Of susceptibility genes investigated for addictions, DRD2 has received much attention. Considering new evidence supporting the association of DRD2 and its adjacent gene ankyrin repeat and kinase domain containing 1 (ANKK1) with various addictions, in this paper, we provide an updated view of the involvement of variants in DRD2 and ANKK1 in the etiology of nicotine dependence (ND) and alcohol dependence (AD) based on linkage, association, and molecular studies. This evidence shows that both genes are significantly associated with addictions; however the association with ANKK1 appears to be stronger. Thus, both more replication studies in independent samples and functional studies of some of these variants are warranted.

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