Association study of 15q14 and 15q25 with high myopia in the Han Chinese population

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• 作者：Yu Qiang (1)
  Wenjin Li (1)
  Qingzhong Wang (1)
  Kuanjun He (1)
  Zhiqiang Li (1)
  Jianhua Chen (1) (2)
  Zhijian Song (1)
  Jia Qu (3)
  Xiangtian Zhou (3)
  Shengying Qin (1)
  Jiawei Shen (1)
  Zujia Wen (1)
  Jue Ji (1)
  Yongyong Shi (1) (4) (5)
  
  1. Bio-X Institutes ; Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) ; Shanghai Jiao Tong University ; Shanghai ; 200030 ; P.R China
  2. Schizophrenia Program ; Shanghai Mental Health Center ; Shanghai Jiao Tong University School of Medicine ; Shanghai ; 200030 ; P.R China
  3. Wenzhou Medical College ; Wenzhou ; 325003 ; P.R China
  4. Shanghai Changning Mental Health Center ; 299 Xiehe Road ; Shanghai ; 200042 ; P.R China
  5. Institute of Neuropsychiatric Science and Systems Biological Medicine ; Shanghai Jiao Tong University ; Shanghai ; 200042 ; P.R China
  
• 关键词：RASGRF1 gene ; High myopia ; Refractive errors ; Single nucleotide polymorphism ; Correlation Analysis
• 刊名：BMC Genetics
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：15
• 期：1
• 全文大小：154 KB
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• 刊物主题：Life Sciences, general; Animal Genetics and Genomics; Microbial Genetics and Genomics; Plant Genetics & Genomics; Genetics and Population Dynamics;
• 出版者：BioMed Central
• ISSN：1471-2156

文摘

Background Refractive errors and high myopia are the most common ocular disorders, and both of them are leading causes of blindness in the world. Recently, genetic association studies in European and Japanese population identified that common genetic variations located in 15q14 and 15q25 were associated with high myopia. To validate whether the same variations conferred risk to high myopia in the Han Chinese population, we genotyped 1,461 individuals (940 controls and 521 cases samples) recruited of Han Chinese origin. Result We found rs8027411 in 15q25 (P = 0.012 after correction, OR = 0.78) was significantly associated with high myopia but rs634990 in 15q14 (P = 0.54 after correction), OR = 0.88) was not. Conclusions Our findings supported that 15q25 is a susceptibility locus for high myopia, and gene RASGRF1 was possible to play a role in the pathology of high myopia.