Synthesis and antimalarial activity of new nanocopolymer β-lactams and molecular docking study of their monomers

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• 作者：Edris Ebrahimi ; Aliasghar Jarrahpour ; Nahid Heidari…
• 关键词：β ; Lactams ; Nanoparticles ; Polyacrylates ; Emulsion polymerization ; Molecular docking
• 刊名：Medicinal Chemistry Research
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：25
• 期：2
• 页码：247-262
• 全文大小：2,012 KB
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• 作者单位：Edris Ebrahimi (1)
  Aliasghar Jarrahpour (1)
  Nahid Heidari (1)
  Véronique Sinou (2)
  Christine Latour (2)
  Jean M. Brunel (3)
  Amin R. Zolghadr (1)
  Edward Turos (4)
  
  1. Department of Chemistry, College of Sciences, Shiraz University, Shiraz, 71946-84795, Iran
  2. UMR-MD3 Relation hôte-parasites, Physiopathologie and Pharmacologie, Faculté de pharmacie, Aix-Marseille Université, Bd Jean Moulin, 13385, Marseille, France
  3. Centre de Recherche en Cancérologie de Marseille (CRCM), UM 105, CNRS, UMR7258, Institut Paoli Calmettes, Inserm, U1068, Faculté de pharmacie, Aix-Marseille Université, Bd Jean Moulin, 13385, Marseille, France
  4. Department of Chemistry, University of South Florida, 4202 E. Fowler Avenue, CHE 205, Tampa, FL, USA
  
• 刊物主题：Pharmacology/Toxicology; Biochemistry, general; Cell Biology;
• 出版者：Springer US
• ISSN：1554-8120

文摘

This report describes the preparation of some new β-lactam nanocopolymers. These nanoparticles are synthesized in water by emulsion polymerization of an acrylate β-lactam pre-dissolved in a mixture of co-monomers in the presence of sodium dodecyl sulfate as a surfactant and potassium persulfate as a radical initiator. Dynamic light scattering analysis and electron microscopy images of these emulsions show that the nanoparticles are approximately 30–70 nm in diameter. These compounds have been evaluated for their antimalarial activities against chloroquine-resistant Plasmodium faliparum K1 strain demonstrating IC₅₀ varying from 14 to 50 µM. The interactions between these β-lactam nanocopolymers and the P. falciparum single-stranded DNA-binding proteins have been studied by molecular docking calculations.