Polymorphisms in gene encoding TRPV1-receptor involved in pain perception are unrelated to chronic pancreatitis

详细信息    查看全文

• 作者：Aura AJ van Esch (1)
  Mark P Lamberts (1)
  René HM te Morsche (1)
  Martijn GH van Oijen (1)
  Jan BMJ Jansen (1)
  Joost PH Drenth (1)
  
• 刊名：BMC Gastroenterology
• 出版年：2009
• 出版时间：December 2009
• 年：2009
• 卷：9
• 期：1
• 全文大小：431KB
• 参考文献：1. Conwell DL, Banks PA: Chronic pancreatitis. / Curr Opin Gastroenterol 2008, 24:586-90. CrossRef
  2. van Esch AA, Wilder-Smith OH, Jansen JB, van GH, Drenth JP: Pharmacological management of pain in chronic pancreatitis. / Dig Liver Dis 2006, 38:518-26. CrossRef
  3. Lieb JG, Forsmark CE: Review article: pain and chronic pancreatitis. / Aliment Pharmacol Ther 2009, 29:706-19. CrossRef
  4. Garg PK, Tandon RK: Survey on chronic pancreatitis in the Asia-Pacific region. / J Gastroenterol Hepatol 2004, 19:998-004. CrossRef
  5. Lazarev M, Lamb J, Barmada MM, Dai F, Anderson MA, Max MB, / et al.: Does the pain-protective GTP cyclohydrolase haplotype significantly alter the pattern or severity of pain in humans with chronic pancreatitis? / Mol Pain 2008, 4:58. CrossRef
  6. Xu GY, Winston JH, Shenoy M, Yin H, Pendyala S, Pasricha PJ: Transient receptor potential vanilloid 1 mediates hyperalgesia and is up-regulated in rats with chronic pancreatitis. / Gastroenterology 2007, 133:1282-292. CrossRef
  7. Liddle RA: The role of Transient Receptor Potential Vanilloid 1 (TRPV1) channels in pancreatitis. / Biochim Biophys Acta 2007, 1772:869-78.
  8. Noble MD, Romac J, Wang Y, Hsu J, Humphrey JE, Liddle RA: Local disruption of the celiac ganglion inhibits substance P release and ameliorates caerulein-induced pancreatitis in rats. / Am J Physiol Gastrointest Liver Physiol 2006, 291:G128-G134. CrossRef
  9. Wick EC, Hoge SG, Grahn SW, Kim E, Divino LA, Grady EF, / et al.: Transient receptor potential vanilloid 1, calcitonin gene-related peptide, and substance P mediate nociception in acute pancreatitis. / Am J Physiol Gastrointest Liver Physiol 2006, 290:G959-G969. CrossRef
  10. Hutter MM, Wick EC, Day AL, Maa J, Zerega EC, Richmond AC, / et al.: Transient receptor potential vanilloid (TRPV-1) promotes neurogenic inflammation in the pancreas via activation of the neurokinin-1 receptor (NK-1R). / Pancreas 2005, 30:260-65. CrossRef
  11. Xue Q, Yu Y, Trilk SL, Jong BE, Schumacher MA: The genomic organization of the gene encoding the vanilloid receptor: evidence for multiple splice variants. / Genomics 2001, 76:14-0. CrossRef
  12. Drenth JP, te MR, Jansen JB: Mutations in serine protease inhibitor Kazal type 1 are strongly associated with chronic pancreatitis. / Gut 2002, 50:687-92. CrossRef
  13. Website of Institute für Humangenetik; tests for Hardy-Weinberg equilibrium[http://ihg2.helmholtz-muenchen.de/cgi-bin/hw/hwa1.pl]
  14. Website of Broad institute: Haploview[http://www.broad.mit.edu/mpg/haploview/]
  15. Romac JM, McCall SJ, Humphrey JE, Heo J, Liddle RA: Pharmacologic disruption of TRPV1-expressing primary sensory neurons but not genetic deletion of TRPV1 protects mice against pancreatitis. / Pancreas 2008, 36:394-01. CrossRef
  16. Kim H, Lee H, Rowan J, Brahim J, Dionne RA: Genetic polymorphisms in monoamine neurotransmitter systems show only weak association with acute post-surgical pain in humans. / Mol Pain 2006, 2:24. CrossRef
  17. Hartel M, di Mola FF, Selvaggi F, Mascetta G, Wente MN, Felix K, / et al.: Vanilloids in pancreatic cancer: potential for chemotherapy and pain management. / Gut 2006, 55:519-28. CrossRef
  18. Xu H, Tian W, Fu Y, Oyama TT, Anderson S, Cohen DM: Functional effects of nonsynonymous polymorphisms in the human TRPV1 gene. / Am J Physiol Renal Physiol 2007, 293:F1865-F1876. CrossRef
  19. Blednov YA, Harris RA: Deletion of vanilloid receptor (TRPV1) in mice alters behavioral effects of ethanol. / Neuropharmacology 2009, 56:814-20. CrossRef
  20. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-230X/9/97/prepub
  
• 作者单位：Aura AJ van Esch (1)
  Mark P Lamberts (1)
  René HM te Morsche (1)
  Martijn GH van Oijen (1)
  Jan BMJ Jansen (1)
  Joost PH Drenth (1)
  
  1. Department of Gastroenterology & Hepatology, Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, P.O. Box 9101, 6500, HB, Nijmegen, The Netherlands
  

文摘

Background The major clinical feature in chronic pancreatitis is pain, but the genetic basis of pancreatic pain in chronic pancreatitis is poorly understood. The transient receptor potential vanilloid receptor 1 (TRPV1) gene has been associated with pain perception, and genetic variations in TRPV1 may modify the presence and phenotype of chronic pancreatitis. The aim of our study was to investigate the genetic variation of TRPV1 in Dutch patients with chronic pancreatitis and healthy controls. Methods We genotyped 4 SNPs (rs222749, rs222747, rs224534 and rs8065080) in 228 chronic pancreatitis-patients and 207 healthy controls by PCR, followed by restriction-fragment-length-polymorphism analysis and DNA sequencing. We generated 27 diplotypes and compared prevalence between patients and controls. Results There was no significant difference in allele frequency of the 4 TRPV1 gene SNPs in patients with chronic pancreatitis and healthy controls. Distribution of diplotypes was not statistically significantly different between patients and controls. Conclusion TRPV1 diplotypes are not associated with chronic pancreatitis.