Influence of the vocal cord mobility in salvage surgery after radiotherapy for early-stage squamous cell carcinoma of the glottic larynx

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• 作者：Philippe Gorphe ; Pierre Blanchard…
• 关键词：Laryngeal carcinoma ; Radiotherapy ; Recurrence ; Laryngeal surgery ; Vocal cord mobility
• 刊名：European Archives of Oto-Rhino-Laryngology
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：272
• 期：10
• 页码：3013-3018
• 全文大小：483 KB
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• 作者单位：Philippe Gorphe (1)
  Pierre Blanchard (2)
  Stephane Temam (1)
  Fran莽ois Janot (1)
  
  1. D茅partement de Canc茅rologie Cervico-Faciale, Institut Gustave Roussy, 104 rue Edouard Vaillant, 94805, Villejuif, France
  2. D茅partement de Radioth茅rapie, Institut Gustave Roussy, 94805, Villejuif, France
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Otorhinolaryngology
  Neurosurgery
  Head and Neck Surgery
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1434-4726

文摘

Disease relapses occur in up to 40 % of cases after radiotherapy (RT) for early-stage glottic laryngeal neoplasms, and the foremost remaining treatment option is salvage total laryngectomy (STL). Our objectives were to review the outcomes of patients treated with salvage surgery after RT for early-stage carcinoma of the glottic larynx and to assess prognostic factors. We retrospectively analyzed 43 patients who underwent surgery. Overall and disease-free survival rates among subgroups were calculated and compared, stratified by preoperative stage, vocal cord mobility and postoperative histopathologic data. Recurrences occurred 22.7 months after the end of RT. Surgery was STL in 33 cases (76.8 %). The main prognostic factors associated with survival rates were initial vocal cord mobility, vocal cord mobility at the diagnosis of recurrence, and changes in mobility. Vocal cord mobility is an important clinical criterion in treatment decision making for early-stage glottis carcinoma and remains important during follow-up. Keywords Laryngeal carcinoma Radiotherapy Recurrence Laryngeal surgery Vocal cord mobility