A single dose of class="a-plus-plus emphasis type-small-caps">l-DOPA changes perceptual experiences and decreases latent inhibition in Parkinson’s disease

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• 作者：Orsolya Györfi ; Helga Nagy ; Magdolna Bokor ; Oguz Kelemen…
• 关键词：Parkinson’s disease ; l ; DOPA ; Latent inhibition ; Psychosis ; Psychotomimetic effects
• 刊名：Journal of Neural Transmission
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：124
• 期：1
• 页码：113-119
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Neurology; Psychiatry; Pharmacology/Toxicology; Neurosciences;
• 出版者：Springer Vienna
• ISSN：1435-1463
• 卷排序：124

文摘

Despite the well-known neuropsychiatric side effects of dopaminergic medications, the possible subjective psychotomimetic effects of a single dose of l-DOPA in newly diagnosed, drug-naïve patients with Parkinson’s disease (PD) are not known. To investigate this question, we used a visual search task for latent inhibition (LI), the Community Assessment of Psychic Experiences (CAPE) scale, and visual analog scales for psychotomimetic effects (perception, relaxation, and dysphoria) in 28 de novo PD patients before (off) and after (on) the adminstration of l-DOPA and in 25 matched healthy control individuals. Results revealed increased LI in PD-off and decreased LI in PD-on relative to the control subjects. After the administration of l-DOPA, we observed a significant decline in LI in PD. l-DOPA also enhanced perceptual experiences (changes in subjective feelings in thinking, time perception, and mental “highness”). Greater reduction in LI was associated with enhanced perceptual experiences. These results suggest that a single dose of l-DOPA has a significant psychotomimetic effect, which is associated with decreased LI, a behavioral marker of psychosis-like experiences.